The ultrastructure of myelin deficiency in Chow Chow dogs was studied in the spinal cord of a 15-month-old and a 3-year-old animal. It was found that myelination progresses with age in these dogs but is still deficient at the age of 3 years. The findings included axons with thin or uncompacted myelin sheaths, separated from each other by massive astrocytosis, and bizarre myelin formations. Normal numbers of morphologically normal oligodendrocytes were present in the myelin-deficient areas. The disease in these Chow Chow dogs consists of a strongly retarded myelination which is possibly due to a dysfunction or delay in glial maturation.
This is a preview of subscription content, log in to check access.
Buy single article
Instant access to the full article PDF.
Price includes VAT for USA
Subscribe to journal
Immediate online access to all issues from 2019. Subscription will auto renew annually.
This is the net price. Taxes to be calculated in checkout.
Blakemore WF (1973) Remyelination of the superior cerebellar peduncle in the mouse following demyelination induced by feeding cuprizone. J Neurol Sci 20:73–83
Done JT (1977) Developmental disorders of the nervous system in animals. Adv Vet Sci Comp Med 21:69–114
Fox WM (1976) Integrative development of brain and behavior in the dog. Univ. of Chicago Press, Chicago London, pp 176–184
Hirano A, Levine S, Zimmerman HM (1968) Remyelination in the central nervous system after cyanide intoxication. J Neuropathol Exp Neurol 27:234–245
Knobler RL, Stempak JG, Laurencin M (1974) Oligodendroglial ensheathment of axons during myelination in the developing rat central nervous system: a serial section electron-microscopical study. J Ultrastruct Res 49:34–49
Ludwin SK (1978) Central nervous system demyelination and remyelination in the mouse. An ultrastructural study on cuprizone toxicity. Lab Invest 39:597–612
Ludwin SK (1980) Chronic demyelination inhibits remyelination in the central nervous system. An analysis of contributing factors. Lab Invest 43:382–387
Omlin FX, Bischoff A (1980) Freeze-fractured glial membrane structures of normal and Jimpy optic nerves before and during myelination. In: Bauman N (ed) Neurological mutations affecting myelination. INSERM Symp. no. 14. Elsevier, North-Holland Biomedical-Press, Amsterdam New York Oxford, pp 123–129
Peters A, Palay SL, Webster H de F (1976) The fine structure of the nervous system: The neurons and supporting cells. WB Saunders, Philadelphia London Toronto, pp 210–212
Raine CS (1977) Morphological aspects of myelin and myelination. In: Morell P (ed) Myelin. Plenum Press, New York London, pp 1–89
Saida K, Sumner AJ, Saida T, Brown MJ, Silberberg DH (1980) Antiserum-mediated demyelination: Relationship between remyelination and functional recovery. Ann Neurol 8:12–24
Skoff RP (1976) Myelin deficit in the Jimpy mouse may be due to cellular abnormalities in astroglia. Nature 264:560–562
Skoff RP (1980) Neuroglia: A reevaluation of their origin and development. Pathol Res Pract 168:279–300
Soffer D, Raine CS (1980) Morphologic analysis of axo-glial membrane specializations in the demyelinated central nervous system. Brain Res 186:301–313
Sweasey D, Patterson DSP (1979) Congenital hypomyelinogenesis (border disease) of lambs: Postnatal neurochemical recovery in the central nervous system. J Neurochem 33:705–711
Vandevelde M, Braund KG, Walker TL, Kornegay JN (1978) Dysmyelination of the central nervous system in the Chow Chow dog. Acta Neuropathol (Berl) 42:211–215
Supported by the Schweizer Nationalfonds grant no. 3.805.79
About this article
Cite this article
Vandevelde, M., Braund, K.G., Luttgen, P.J. et al. Dysmyelination in Chow Chow dogs: Further studies in older dogs. Acta Neuropathol 55, 81–87 (1981). https://doi.org/10.1007/BF00699232
- Canine CNS
- Electron microscopy