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Dysmyelination in Chow Chow dogs: Further studies in older dogs

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Summary

The ultrastructure of myelin deficiency in Chow Chow dogs was studied in the spinal cord of a 15-month-old and a 3-year-old animal. It was found that myelination progresses with age in these dogs but is still deficient at the age of 3 years. The findings included axons with thin or uncompacted myelin sheaths, separated from each other by massive astrocytosis, and bizarre myelin formations. Normal numbers of morphologically normal oligodendrocytes were present in the myelin-deficient areas. The disease in these Chow Chow dogs consists of a strongly retarded myelination which is possibly due to a dysfunction or delay in glial maturation.

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References

  1. Blakemore WF (1973) Remyelination of the superior cerebellar peduncle in the mouse following demyelination induced by feeding cuprizone. J Neurol Sci 20:73–83

  2. Done JT (1977) Developmental disorders of the nervous system in animals. Adv Vet Sci Comp Med 21:69–114

  3. Fox WM (1976) Integrative development of brain and behavior in the dog. Univ. of Chicago Press, Chicago London, pp 176–184

  4. Hirano A, Levine S, Zimmerman HM (1968) Remyelination in the central nervous system after cyanide intoxication. J Neuropathol Exp Neurol 27:234–245

  5. Knobler RL, Stempak JG, Laurencin M (1974) Oligodendroglial ensheathment of axons during myelination in the developing rat central nervous system: a serial section electron-microscopical study. J Ultrastruct Res 49:34–49

  6. Ludwin SK (1978) Central nervous system demyelination and remyelination in the mouse. An ultrastructural study on cuprizone toxicity. Lab Invest 39:597–612

  7. Ludwin SK (1980) Chronic demyelination inhibits remyelination in the central nervous system. An analysis of contributing factors. Lab Invest 43:382–387

  8. Omlin FX, Bischoff A (1980) Freeze-fractured glial membrane structures of normal and Jimpy optic nerves before and during myelination. In: Bauman N (ed) Neurological mutations affecting myelination. INSERM Symp. no. 14. Elsevier, North-Holland Biomedical-Press, Amsterdam New York Oxford, pp 123–129

  9. Peters A, Palay SL, Webster H de F (1976) The fine structure of the nervous system: The neurons and supporting cells. WB Saunders, Philadelphia London Toronto, pp 210–212

  10. Raine CS (1977) Morphological aspects of myelin and myelination. In: Morell P (ed) Myelin. Plenum Press, New York London, pp 1–89

  11. Saida K, Sumner AJ, Saida T, Brown MJ, Silberberg DH (1980) Antiserum-mediated demyelination: Relationship between remyelination and functional recovery. Ann Neurol 8:12–24

  12. Skoff RP (1976) Myelin deficit in the Jimpy mouse may be due to cellular abnormalities in astroglia. Nature 264:560–562

  13. Skoff RP (1980) Neuroglia: A reevaluation of their origin and development. Pathol Res Pract 168:279–300

  14. Soffer D, Raine CS (1980) Morphologic analysis of axo-glial membrane specializations in the demyelinated central nervous system. Brain Res 186:301–313

  15. Sweasey D, Patterson DSP (1979) Congenital hypomyelinogenesis (border disease) of lambs: Postnatal neurochemical recovery in the central nervous system. J Neurochem 33:705–711

  16. Vandevelde M, Braund KG, Walker TL, Kornegay JN (1978) Dysmyelination of the central nervous system in the Chow Chow dog. Acta Neuropathol (Berl) 42:211–215

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Author information

Correspondence to M. Vandevelde.

Additional information

Supported by the Schweizer Nationalfonds grant no. 3.805.79

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Vandevelde, M., Braund, K.G., Luttgen, P.J. et al. Dysmyelination in Chow Chow dogs: Further studies in older dogs. Acta Neuropathol 55, 81–87 (1981). https://doi.org/10.1007/BF00699232

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Key words

  • Canine CNS
  • Myelination
  • Hypomyelinogenesis
  • Electron microscopy