The prognostic significance of nuclear count, nuclear area fraction, and mean nuclear area estimated by automatic image analysis was evaluated in benign meningiomas. One hundred thirty-two meningiomas without recurrences, 39 meningiomas that recurred, and 40 first recurrences were examined. The tumors were classified according to age and eex of patients, localization, and histology; and the correlation between these parameters and the recurrence rate was assessed.
The nuclear counts were identical in paraffin sections from meningiomas without recurrences (6.1 nuclei per 1,000 μm2) and in meningiomas that recurred (6.4 nuclei per 1,000 μm2). The cell count in the recurrences (7.4 nuclei per 1,000 μm2) was higher than in the primary tumors. The same relationship was found for the nuclear area fractions, which were identical in primary meningiomas without recurrences and in meningiomas that recurred. The nuclear area fraction was increased in recurrences. The mean nuclear areas were identical in all groups. The histological type was of little significance in prediction of recurrence rate, although bone invasion and necrosis were of some significance. We found a higher recurrence rate in parasagittal meningiomas. Meningiomas that recurred appeared in a younger age group than other meningiomas, and the recurrence rate was higher for males than for females.
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Adegbite AB, Khan MI, Paine KWE, Tan LK (1983) The recurrence of intracranial meningiomas after surgical treatment. J Neurosurg 58:51–56
Crompton MR, Gautier-Smith PC (1970) The prediction of recurrence in meningiomas. J Neurol Neurosurg Psychiatry 33:80–87
Henschen F (1955) Tumoren des Zentralnervensystems und seiner Hüllen. In: Lubarsch O, Henke F, Rössle R (Hrsg) Handbuch der speziellen pathologischen Anatomie und Histologie. Springer, Berlin Göttingen Heidelberg, pp 441–496
Jellinger K, Slowik F (1975) Histological subtypes and prognostic problems in meningiomas. J Neurol 208:279–298
Jänisch W, Güthert H, Schreiber D (1976) Pathologie der Tumoren des Zentralnervensystems. Fischer Jena
Laursen H, Diemer NH (1980) Capillary size, density and ultrastructure in brain of rats with urease-induced hyperammoniaemia. Acta Neurol Scand 62:103–115
MacCarty CS, Taylor WF (1979) Intracranial meningiomas: Experiences at the Mayo Clinic. Neurol Med Chir (Tokyo) 19:569–574
Melamed S, Sahar A, Beller AJ (1979) The recurrence of intracranial meningiomas. Neurochirurgia 22:47–51
Rocher A (1979) Beitrag zur Kenntnis der Meningioma-Rezidive. Thesis, Pathologisches Institut der Universität Köln
Rubinstein LJ (1972) Tumors of the central nervous system. Armed Forces Institute of Pathology, Stanford, California
Simpson D (1957) The recurrence of intracranial meningiomas after surgical treatment. J Neurol Neurosurg Psychiatry 20:22–39
Skullerud K, Löken AC (1974) The prognosis in meningiomas. Acta Neuropathol (Berl) 29:337–344
Tamura M, Kawafuchi J, Inoue H, Takada F (1979) Prognosis in meningioma after surgical treatment. Neurol Med Chir (Tokyo) 19:411–419
Supported by grant no. 512-10141 from the Danish Medical Research Council
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Christensen, D., Laursen, H. & Klinken, L. Prediction of recurrence in meningiomas after surgical treatment. Acta Neuropathol 61, 130–134 (1983). https://doi.org/10.1007/BF00697392
- Recurrence rate
- Automatic image analysis