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Ultrastructure of the syndrome of continuous muscle fibre activity

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Summary

The ultrastructure of muscle and the myoneural junction of a man of 60 suffering from the syndrome of continuous muscle fibre activity was studied. This syndrome is manifested by disturbances of walking, muscle weakness, permanent muscle contractions and involuntary movements. The myoneural junction was hypertrophied and showed ramifications of the secondary clefts. The presynaptic nerve ending contained no synaptic vesicles. The relationship of these findings to the disease is discussed.

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References

  1. Allen, D. E., Johnson, A. G., Woolf, A. L.: The intramuscular nerve endings in dystrophia myotonica—a biopsy by vital staining and electron microscopy. J. Anat. (Lond.)105, 1–26 (1969)

  2. Chen, I-Li, Lee, C. Y.: Ultrastructural changes in the motor nerve terminals caused by betabungarotoxin. Virchows Arch., Abt. B, Zellpath.6, 318–325 (1970)

  3. Clark, A. W., Hurlbut, W. P., Mauro, A.: Changes in the fine structure of the neuromuscular junction of the frog caused by black widow spider venom. J. Cell Biol.52, 1–14 (1972)

  4. Duchen, L. W.: An electron microscopic study of the changes induced by botulinum toxin in the motor end-plates of slow and fast skeletal muscle fibres of the mouse. J. neurol. Sci.14, 47–60 (1971)

  5. Engel, A. G., Santa, T.: Effect of long-term anticholinesterase on neuromuscular transmission and on motor end-plate fine structure. Neurology (Minneap.)22, 401–402, abstr. (1972)

  6. Gilbert, J. J., Steinberg, M. C., Banker, B. Q.: Ultrastructural alterations of the motor end plate in myotonic dystrophy of the mouse (dy2J/dy2J). J. Neuropath. exp. Neurol.32, 345–364 (1973)

  7. Hughes, C. R. S., Matthews, W. R.: Pseudo-myotonia and myokymia. J. Neurol. Neurosurg. Psychiat.32, 11–14 (1969)

  8. Isaacs, H.: A syndrome of continuous muscle fibre activity. J. Neurol. Neurosurg. Psychiat.24, 319–325 (1961)

  9. Isaacs, H.: Continuous muscle fibre activity in an Indian man with additional evidence of terminal motor fibre abnormality. J. Neurol. Neurosurg. Psychiat.30, 126–133 (1967)

  10. Mertens, H. G., Zschoche, S.: Neuro-myotonia. Klin. Wschr.43, 917–925 (1965)

  11. Santa, T., Engel, A. G., Lambert, E. H.: Histometric study of neuromuscular junction ultrastructure. I. Myasthenia Gravis. Neurology (Minneap.)22, 71–82 (1972)

  12. Santa, T., Engel, A. G. S., Lambert, E. H.: Histometric study of neuromuscular junction ultrastructure. II. Myasthenic syndrome. Neurology (Minneap.)22, 370–376 (1972)

  13. Sigwald, J., Raverdy, Ph., Fardeau, M., Gremy, F., Lepinay, A. M. de, Bouttier, D., Danic, M.: Pseudomyotonie. Rev. neurol.115, 1003–1015 (1966)

  14. Sigwald, J. S., Guilleminault, C.: Syndrome de contracture permanente. Rev. neurol.124, 191–212 (1971)

  15. Song, S. K.: Electron microscopic study of terminal nerves, motor end-plates and sarcoplasmic structures in denervated skeletal muscle. J. Neuropath. exp. Neurol.27, 108, Abstr. (1972)

  16. Yarom, R., Chaco, J. S., Steigbuegel, D.: Ultrastructure of muscle in Stiff-Man Syndrome. Virchows Arch., Abt. A, Path. Anat.362, 207–221 (1974)

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Sroka, H., Bornstein, B. & Sandbank, U. Ultrastructure of the syndrome of continuous muscle fibre activity. Acta Neuropathol 31, 85–90 (1975). https://doi.org/10.1007/BF00696889

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Key words

  • Electronmicroscopy
  • Continuous Muscle Fibre Activity