Unusual tubular inclusions were observed in the cytoplasm of ganglion cells of a mediastinal ganglioneuroma in a boy of 7 years. The inclusions consisted of an aggregation of about 100-nm-sized tubular structures resembling ‘honeycomb-like’ tubular structures in the axoplasm of rats and mice and suggested to be derived from dilated rough endoplasmic reticulum. These structures differ from profiles reported in normal and pathologic conditions and seem to be related to the neoplastic character of the ganglion cells.
This is a preview of subscription content, log in to check access.
Buy single article
Instant access to the full article PDF.
Price includes VAT for USA
Subscribe to journal
Immediate online access to all issues from 2019. Subscription will auto renew annually.
This is the net price. Taxes to be calculated in checkout.
Bender BL, Ghatak NR (1978) Light-and electron-microscopic observations on a ganglioneuroma. Acta Neuropathol (Berl) 42:7–10
Fawcett DW (1981) Endoplasmic reticulum. The cell, 2nd edn. Saunders, Philadelphia London Toronto, pp 303–368
Friede RL, Bischhausen R (1979) Production of myelin by neoplastic cells. Acta Neuropathol (Berl) 45:241–245
Henderson DW, Papadimitriou JM (1982) Adenocarcinomas. Ultrastructural appearances of tumors. A diagnostic atlas. Churchill Livingstone, Edinburgh, pp 71–96
Hirano A, Rubin R, Sutton CH, Zimmerman HM (1968) Honeycomb-like tubular structure in axoplasm. Acta Neuropathol (Berl) 10:17–25
Jellinger K (1973) Neuroaxonal dystrophy — Its natural history and related disorders. Prog Neuropathol 2:129–180
Pearl GS, Mirra SS, Miles ML (1978) Intracerebral ganglioneuroblastoma with intracytoplasmic microtubular aggregates: Case report and ultrastructural study. Ultrastruct Pathol 2:337–342
Poon TP, Hirano A, Zimmerman HM (1979) Nervous system, sensory organs and respiratory tract. In: Johannessen JV (ed) Electron microscopy in human medicine, vol 6. McGraw-Hill, New York, pp 85–134
Powers JM, Balentine JD, Wisniewski HM, Terry RD (1976) Retroperitoneal ganglioneuroblastoma: A kaleidoscope of neuronal degeneration. A light- and electron-microscopic study. J Neuropathol Exp Neurol 35:14–25
Rubinstein LJ, Herman MM (1979) Recent advances in human neuro-oneology, Recent Adv Neuropathol 1:179–223
Staley NA, Polesky HF, Bensch KG (1967) Fine structural and biochemical studies on the malignant ganglioneuroma. J Neuropathol Exp Neurol 26:634–653
Yokoyama M, Okada K, Tokue A, Takayasu H (1973) Ultrastrucural and biochemical study of benign ganglioneuroma. Virchows Arch [Pathol Anat] 361:195–209
Zollinger HU, Mihatsch MJ (1978) Kidney tumors. In: Castagnolli E (ed) Renal pathology in biopsy. Springer, Berlin Heidelberg New York, pp 553–563
About this article
Cite this article
Matsuda, M., Nagashima, K. Cytoplasmic tubular inclusion in ganglioneuroma. Acta Neuropathol 64, 81–84 (1984). https://doi.org/10.1007/BF00695612
- Cytoplasmic tubular inclusion
- Smooth endoplasmic reticulum