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Cytoplasmic tubular inclusion in ganglioneuroma

Summary

Unusual tubular inclusions were observed in the cytoplasm of ganglion cells of a mediastinal ganglioneuroma in a boy of 7 years. The inclusions consisted of an aggregation of about 100-nm-sized tubular structures resembling ‘honeycomb-like’ tubular structures in the axoplasm of rats and mice and suggested to be derived from dilated rough endoplasmic reticulum. These structures differ from profiles reported in normal and pathologic conditions and seem to be related to the neoplastic character of the ganglion cells.

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References

  1. 1.

    Bender BL, Ghatak NR (1978) Light-and electron-microscopic observations on a ganglioneuroma. Acta Neuropathol (Berl) 42:7–10

  2. 2.

    Fawcett DW (1981) Endoplasmic reticulum. The cell, 2nd edn. Saunders, Philadelphia London Toronto, pp 303–368

  3. 3.

    Friede RL, Bischhausen R (1979) Production of myelin by neoplastic cells. Acta Neuropathol (Berl) 45:241–245

  4. 4.

    Henderson DW, Papadimitriou JM (1982) Adenocarcinomas. Ultrastructural appearances of tumors. A diagnostic atlas. Churchill Livingstone, Edinburgh, pp 71–96

  5. 5.

    Hirano A, Rubin R, Sutton CH, Zimmerman HM (1968) Honeycomb-like tubular structure in axoplasm. Acta Neuropathol (Berl) 10:17–25

  6. 6.

    Jellinger K (1973) Neuroaxonal dystrophy — Its natural history and related disorders. Prog Neuropathol 2:129–180

  7. 7.

    Pearl GS, Mirra SS, Miles ML (1978) Intracerebral ganglioneuroblastoma with intracytoplasmic microtubular aggregates: Case report and ultrastructural study. Ultrastruct Pathol 2:337–342

  8. 8.

    Poon TP, Hirano A, Zimmerman HM (1979) Nervous system, sensory organs and respiratory tract. In: Johannessen JV (ed) Electron microscopy in human medicine, vol 6. McGraw-Hill, New York, pp 85–134

  9. 9.

    Powers JM, Balentine JD, Wisniewski HM, Terry RD (1976) Retroperitoneal ganglioneuroblastoma: A kaleidoscope of neuronal degeneration. A light- and electron-microscopic study. J Neuropathol Exp Neurol 35:14–25

  10. 10.

    Rubinstein LJ, Herman MM (1979) Recent advances in human neuro-oneology, Recent Adv Neuropathol 1:179–223

  11. 11.

    Staley NA, Polesky HF, Bensch KG (1967) Fine structural and biochemical studies on the malignant ganglioneuroma. J Neuropathol Exp Neurol 26:634–653

  12. 12.

    Yokoyama M, Okada K, Tokue A, Takayasu H (1973) Ultrastrucural and biochemical study of benign ganglioneuroma. Virchows Arch [Pathol Anat] 361:195–209

  13. 13.

    Zollinger HU, Mihatsch MJ (1978) Kidney tumors. In: Castagnolli E (ed) Renal pathology in biopsy. Springer, Berlin Heidelberg New York, pp 553–563

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Correspondence to K. Nagashima.

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Matsuda, M., Nagashima, K. Cytoplasmic tubular inclusion in ganglioneuroma. Acta Neuropathol 64, 81–84 (1984). https://doi.org/10.1007/BF00695612

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Key words

  • Ganglioneuroma
  • Cytoplasmic tubular inclusion
  • Smooth endoplasmic reticulum
  • Ultrastructure