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Hyperlipemic polyneuropathy

Case report: Histological and electron-microscopical study


A 73 old patient with very high serum lipids suffered from recurrent peripherad polyneuropathy. Examination of sural nerve showed disorganisation of myelin sheaths ann plasma membrane invaginations into the axons which seems to represent both Schwanl cell and axonal membranes.

An extensive basal membrane hyperplasia and perineural connective tissue proliferation were present. The possibility that these changes are related to the patient's hyperlipemia is discussed.

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Sandbank, U., Bechar, M. & Bornstein, B. Hyperlipemic polyneuropathy. Acta Neuropathol 19, 290–300 (1971).

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Key words

  • Polyneuropathy
  • Hyperlipemia
  • Electron Microscopy
  • Myelin Disorganization
  • Membrane Invagination