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Ultrastructure of neurofibrillary tangles in progressive supranuclear palsy

Summary

The fine structure of neurofibrillary tangles in the hippocampal gyrus, substantia nigra, pontine nuclei and locus coeruleus of the brain was postmortem studied in a case of progressive supranuclear palsy. Straight tubules and twisted tubules were observed in both the cortical and subcortical neurofibrillary tangles. Most tubules appeared separately in each neuron but a few straight tubules were mixed with the twisted tubules in the cortical tangles. The implication and possible significance of this findings are discussed.

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References

  1. Bugiani, L., Mancardi, G. L., Brusa, A., Ederli, E.: The fine structure of subcortical neurofibrillary tangles in progressive supranuclear palsy. Acta Neuropathol. (Berl.)45, 147–152 (1979)

  2. Ishii, Y., Itoh, T.: Anautopsy case of progressive supranuclear palsy. Clin. Neurol. (Tokyo)19, 187 (1979)

  3. Ishino, H., Ikeda, H., Otsuki, S.: Progressive supranuclear palsy. Review of the literature with presentation of a case. Folia Psychiat. Neurol. Jpn.28, 187–196 (1974)

  4. Kuroda, S., Hirano, A., Otsuki, S.: A case of quadriplegia and myoclonic movement with massive neurofibrillary changes. II. Further neuropathological study. Neurol. Med. Chir. (Tokyo)10, 44–49 (1979)

  5. Lampert, P.: Fine structural changes of neurites in Alzheimer's disease. Acta Neuropathol. (Berl.) [Suppl. V] 49–53 (1971)

  6. Oyanagi, S.: An electron microscopic observation on senile dementia, with special references to transformation of neurofilaments to twisted tubules and a structural connection of Pick bodies to Alzheimer's neurofibrillary changes. Adv. Neurol. (Jpn.)18, 77–88 (1974)

  7. Powell, H., London, G., Lampert, P.: Neurofibrillary tangles in progressive supranuclear palsy. Electron microscopic observations. J. Neuropathol. Exp. Neurol.26, 637–653 (1974)

  8. Probst, A.: Dégénérescence de neurofibrillaire sous-corticale senile avec presence de tubule contournes et de filaments droits. Forme atypique de la paralysie supranucleaire progressive. Rev. Neurol. (Paris)133, 417–428 (1977)

  9. Roy, S., Hirano, A., Ghatak, N. R., Zimmermann, H. M.: Electron microscopic study of neurofibrillary tangles in Steele-Richardson-Olszewski syndrome. Acta Neuropathol. (Berl.)29, 175–179 (1974)

  10. Steele, J. C., Richardson, J. C., Olszewski, J.: Progressive supranuclear palsy. A heterogeneous degeneration involving the brain stem, basal ganglia and cerebellum with vertical gaze and pseudobulbar palsy, nuchal dystonia, and dementia. Arch. Neurol.10, 333–359 (1964)

  11. Tellez-Nagel, I., Wisniewski, H. M.: Ultrastructure of neurofibrillary tangles in Steele-Richardson-Olszewski syndrome. Arch. Neurol.29, 324–327 (1973)

  12. Terry, R. D.: Neuronal fibrous protein in human pathology. J. Neuropathol. Exp. Neurol.30, 8–19 (1971)

  13. Tomonaga, M.: Ultrastructure of neurofibrillary tangles in progressive supranuclear palsy. Acta Neuropathol. (Berl.)37, 177–181 (1977)

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Correspondence to S. Yagishita.

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Yagishita, S., Itoh, Y., Amano, N. et al. Ultrastructure of neurofibrillary tangles in progressive supranuclear palsy. Acta Neuropathol 48, 27–30 (1979). https://doi.org/10.1007/BF00691787

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Key words

  • Progressive supranuclear palsy
  • Neurofibrillary tangles
  • Ultrastructure
  • Straight tubule
  • Twisted tubule