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Experimental studies on the pathogenesis of leucodystrophies

III. Cellular accumulation of injected sulphatides in brain, peripheral nerve and kidney

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Summary

Cellular accumulation of sulphatides after intracerebral and endoneurial injections of the lipid was shown to occur if mesenchymal cell proliferation is induced by cold injury to the brain or by transection of peripheral nerves. The cells accumulating the sulphatide in the brain were identified as mesenchymal phagocytes and in the peripheral nerves as endoneurial phagocytic cells.

Accumulation of sulphatide was found in the epithelial cells of the renal collecting tubules after intracerebral injection of the lipid. This observation indicates that part of the renal sulphatide which can be demonstrated histochemically in the kidneys from cases of metachromatic leucodystrophy may derive from the brain and is excreted via the kidneys.

Zusammenfassung

Celluläre Anhäufung von Sulfatiden nach intracerebralen und endoneuralen Injektionen des Lipids konnte nachgewiesen werden, wenn eine Proliferation von Mesenchymzellen durch Kälteverletzung des Gehirns oder durch Durchschneidung peripherer Nerven induziert wurde. Die mit Sulfatiden beladenen Zellen im Gehirn wurden als mesenchymale Phagocyten und in den peripheren Nerven als endoneurale Phagocytenzellen identifiziert.

Anhäufung von Sulfatiden wurde nach intracerebraler Injektion des Lipids ferner in den Epithelzellen der Sammelstücke der Nierentubuli nachgewiesen. Dieser Befund weist darauf hin, daß ein Teil des renalen Sulfatides, das histochemisch in der Niere von Fällen metachromatischer Leukodystrophie nachgewiesen werden kann, teilweise aus dem Gehirn stammen könnte und über die Nieren ausgeschieden wird.

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Hansson, H., Olsson, Y. & Sourander, P. Experimental studies on the pathogenesis of leucodystrophies. Acta Neuropathol 9, 134–140 (1967). https://doi.org/10.1007/BF00691438

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Keywords

  • Public Health
  • Lipid
  • Cell Proliferation
  • Epithelial Cell
  • Experimental Study