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Lewy bodies in cerebral cortex. Report of three cases


The histochemical and structural properties and the topographical distribution pattern of Lewy bodies in the cerebral cortex as well as in the brain stem and diencephalon were studied in three cases.

The Lewy bodies in the cerebral cortex were found in the small or medium-sized neurons of the fifth and sixth layers, particularly in the anterior frontal, temporal, insular, and cingulate cortex, and showed minor differences in their histochemical and structural properties from typical Lewy bodies in the brain stem and diencephalon. By light microscopy they were more irregular in shape, less eosinophilic, less sharply demarcated, and did not have clear halos and central cores. From the ultrastructural aspect, the filaments in them did not radiate, but were arranged at random, and circular profiles were not associated in the central zone. This type of Lewy body was also distributed in the basal ganglia. A close relationship between Lewy bodies and monoamines in the cerebral cortex of our cases was not recognized. These three cases showed also concomitant senile changes, i.e., senile plaques and neurofibrillary tangles.

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Supported in part by a scholarship in Max-Planck-Institut für Psychiatrie (München)

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Kosaka, K. Lewy bodies in cerebral cortex. Report of three cases. Acta Neuropathol 42, 127–134 (1978).

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Key words

  • Lewy body
  • “Cerebral type” of Lewy body
  • Monoamines
  • Dementia
  • Senile changes