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Cerebrovascular pathogenesis in the telencephalon of the loop-tail mouse: A transmission electron-microscopic study

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Cerebral capillaries in the telencephalon of normal (+/+;Lp/+)_and abnormal (Lp/Lp) loop-tail mutant mice were studied chronologically by means of electron microscopy at stages ranging from 15 through 18 days of gestation. In the abnormal tissue, neural rosettes were common, and cellular material and red blood cells were often contained within the lumen of the rosettes. The endothelial cells of telencephalic blood vessels in the abnormal brains showed a persistence of cellular projections, subluminal vacuoles, and swollen mitochondria beyond the stage when these features ordinarily disappear in normal embryonic cerebral vessels. The endothelial cells in the abnormal brains also failed to become fully invested with pericytes, and red blood cells gradually infiltrated the neural tissue, particularly in subependymal regions, at 16–18 days of gestation.

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Supported by research grant HD 09562 from the National Institute of Child Health and Human Development, USPHS

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Wilson, D.B. Cerebrovascular pathogenesis in the telencephalon of the loop-tail mouse: A transmission electron-microscopic study. Acta Neuropathol 58, 177–182 (1982). https://doi.org/10.1007/BF00690798

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Key words

  • Cerebral vessels
  • Telencephalon
  • Looptail mutant mouse
  • Pathogenesis
  • Electron microscopy