Mast cell proliferation has been reported in peripheral nerves of streptozotocin diabetic rats. We examined the question by light microscopy using morphometric techniques including estimation of shape and size.
After 4 weeks of diabetes the mast cell area in transverse sections was 32.7±7.0 μm2 vs. 22.5±5.4 μm2 in controls (P<102). Mast cell profiles approximated to ellipses in longitudinal sections, the long diameter being 11.4±1.2 μm vs. 14.0±1.0 μm in controls (P<104). Correspondingly, the profile number was increased (30 ±6%) in longitudinal sections and decreased in transverse sections (11±16%).
The present study does not provide evidence for mast cell proliferation in peripheral nerves in experimental diabetes, and, furthermore, underlines the need of evaluation of dimensions in studies of particle numbers.
This is a preview of subscription content, log in to check access.
Buy single article
Instant access to the full article PDF.
Price includes VAT for USA
Subscribe to journal
Immediate online access to all issues from 2019. Subscription will auto renew annually.
This is the net price. Taxes to be calculated in checkout.
Dasgupta SR, Maiti AK (1979) Proliferation of mast cells in peripheral nerve of alloxan diabetic rat. Indiant J Exp Biol 17:455–459
Jakobsen J (1978) Peripheral nerves in early experimental diabetes. Expansion of the endoneurial space as a cause of increased water content. Diabetologia 14:113–119
Jakobsen J (1979) Early and preventable changes of periphrals nerve structure and function in insulin-deficiency diabetic rat. J Neurol Neurosurg Psychiat 42:509–518
Malmgren LT, Jakobsen J, Olsson Y (1979) Permeability of blood-nerve barrier in galactose-fed rats. Exp Neurol 66:758–770
Olsson Y, Enerbäck L, Sourander P (1965) Mast cells in normal and sectioned peripheral nerve. Z Zellforsch 66:596–608
Sidenius P, Jakobsen J (1981) Retrograde axonal transport. A possible role in the development of neuropathy. Diabetologia 20:110–112
About this article
Cite this article
Jakobsen, J., Jensen, H.D. & Sidenius, P. Change in mast cell dimensions increases the profile number in sections of peripheral nerve of diabetic rats. Acta Neuropathol 56, 157–160 (1982). https://doi.org/10.1007/BF00690588
- Diabetic neuropathy
- Streptozotocin diabetes
- Mast cells
- Peripheral nerves