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Change in mast cell dimensions increases the profile number in sections of peripheral nerve of diabetic rats

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Mast cell proliferation has been reported in peripheral nerves of streptozotocin diabetic rats. We examined the question by light microscopy using morphometric techniques including estimation of shape and size.

After 4 weeks of diabetes the mast cell area in transverse sections was 32.7±7.0 μm2 vs. 22.5±5.4 μm2 in controls (P<102). Mast cell profiles approximated to ellipses in longitudinal sections, the long diameter being 11.4±1.2 μm vs. 14.0±1.0 μm in controls (P<104). Correspondingly, the profile number was increased (30 ±6%) in longitudinal sections and decreased in transverse sections (11±16%).

The present study does not provide evidence for mast cell proliferation in peripheral nerves in experimental diabetes, and, furthermore, underlines the need of evaluation of dimensions in studies of particle numbers.

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Correspondence to J. Jakobsen.

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Jakobsen, J., Jensen, H.D. & Sidenius, P. Change in mast cell dimensions increases the profile number in sections of peripheral nerve of diabetic rats. Acta Neuropathol 56, 157–160 (1982). https://doi.org/10.1007/BF00690588

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Key words

  • Diabetic neuropathy
  • Streptozotocin diabetes
  • Mast cells
  • Peripheral nerves
  • Morphometry