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Sudanophilic lipid accumulation in astrocytes in periventricular leukomalacia in monkeys

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Summary

Sudanophilic lipid accumulation is a characteristic feature of periventricular leukomalacia (PVL) of infants. At least two types of lipid-containing cells have been identified, one being the macrophage, the other the “pre-myelin glial cell”. A third type of lipid-containing cell has been seen in two monkeys with spontaneous PVL. Electron microscopically this cell appears to be an astrocyte. This probably represents a reaction of the astrocyte to hypoxia and may be the equivalent of the “hypertrophic” astrocytes found in human infants.

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Correspondence to S. Mark Sumi.

Additional information

Supported in part by NIH grant HDO 8633 and the Regional Primate Research Center Grant RR-00166

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Sumi, S.M. Sudanophilic lipid accumulation in astrocytes in periventricular leukomalacia in monkeys. Acta Neuropathol 47, 241–243 (1979). https://doi.org/10.1007/BF00690553

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Key words

  • Astrocytes
  • Sudanophilic lipids
  • Periventricular leukomalacia