In a study of experimental autolysis of peripheral nerves of normal Wistar rats, crystalloid inclusions similar to Hirano bodies were observed. They occurred in the nuclei and cytoplasms of Schwann cells and in myelinated axons. They first developed after a 12-h autolysis and increased in number and size with time. Their fine structure, localization, and morphogenesis are discussed in relation to the autolysis of the cellular organelles.
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Anzil, A. P., Herrlinger, H., Blinzinger, K., Heldrich, A.: Ultrastructure of brain and nerve biopsy in Wilson disease. Arch. Neurol.31, 94–100 (1974)
Arsenio-Nunes, M. L., Goutieres, F.: Diagnosis of infantile neuroaxonal dystrophy by conjunctival biopsy. J. Neurol. Neurosurg. Psychiatry41, 511–515 (1978)
Brown, H. R., Jervis, G. A., Thormar, H.: Ultrastructural and histological studies of brains of ferrets inoculated with subacute sclerosing panencephalitis: Similarities to human disease. J. Neuropathol. Exp. Neurol.36, 653–665 (1977)
Bird, T. D., Shaw, C. M.: Progressive myoclonus epilepsy with dentatorubral degeneration: a clinicopathological study of the Ramsay Hunt syndrome. J. Neurol. Neurosurg. Psychiatry41, 140–149 (1978)
Cavanagh, J. B., Blakemore, W. F., Kyu, M. H.: Fibrillary accumulations in oligodendroglial processes of rats subjected to portocaval anastomosis. J. Neurol. Sci.14, 143–152 (1971)
Fu, Y. S., Ward, J., Young, H. F.: Unusual rod-shaped cytoplasmic inclusions (Hirano bodies) in a cerebellar hemangioblastoma. Acta Neuropathol. (Berl.)31, 129–135 (1975)
Gessaga, E. C.: Rod-shaped filamentous inclusions and other ultrastructural features in a cerebellar astrocytoma. Acta Neuropathol. (Berl.)33, 119–127 (1975)
Gibson, P. H., Tomlinson, B. E.: Numbers of Hirano bodies in the hippocampus of normal and demented people with Alzheimer's disease. J. Neurol. Sci.33, 199–206 (1977)
Gibson, P. H.: Light and electron microscopic observations on the relationship between Hirano bodies, neuron and glial perikarya in the human hippocampus. Acta Neuropathol. (Berl.)42, 166–171 (1978)
Hadfield, M. G., Martinez, A. J., Gilmartin, R.: Progressive multifocal leukoencephalopathy with paramyxovirus-like structures, Hirano bodies and neurofibrillary tangles. Acta Neuropathol. (Berl.)27, 277–288 (1974)
Hirano, A.: Fine structural changes in the mutant hamster with hind leg paralysis. Acta Neuropathol. (Berl.)39, 225–230 (1977)
Hirano, A., Malamud, N., Elizan, T. S., Kurland, L. T.: Amyotrophic lateral sclerosis and parkinsonism-dementia complex on Guam. Arch. Neurol.15, 33–51 (1966)
Karasek, J.: Ultrastructural nuclear changes of extranucleolar ribonucleoprotein structures during autolysis of normal liver cells. Virchows Archiv [Cell Pathol.]18, 337–346 (1975)
Ogata, J., Budzilovich, G. N., Cratioto, H.: A study of rod-like structures (Hirano bodies) in 240 normal and pathological brains. Acta Neuropathol. (Berl.)21, 61–67 (1972)
Ramsay, J. H.: Altered synaptic terminals in the cortex near tumor. Am. J. Pathol.51, 1093–1109 (1967)
Rees, S.: A quantitative electron-microscopic study of the aging human cerebral cortex. Acta Neuropathol. (Berl.)36, 347–362 (1976)
Schochet, S. S., McCormick, W. F.: Ultrastructure of Hirano bodies. Acta Neuropathol. (Berl.)21, 50–60 (1972)
Tomonaga, M.: Ultrastructure of Hirano bodies. Acta Neuropathol. (Berl.)28, 365–366 (1974)
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Yagishita, S., Itoh, Y., Nakano, T. et al. Crystalloid inclusions reminiscent of Hirano bodies in autolyzed peripheral nerve of normal Wistar rats. Acta Neuropathol 47, 231–236 (1979). https://doi.org/10.1007/BF00690551
- Hirano bodies
- Peripheral nerve
- Wistar rat