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Alterations in cat cerebrocortical capillary morphometrical parameters following K+-induced cerebrocortical swelling

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Histochemical, electron microscopic, and morphometrical techniques were employed in the determination of the effects attributed to K+-induced cerebrocortical swelling on cat cerebrocortical capillary diameter, length, surface area, volume, and minimal intercapillary distance.

Bilaterally exposed and intact temporoparietal cerebral cortices of 4 conditioned adult cats were simultaneously superfused with isotonic, artificial CSF containing 3.5 mM K+ (control) and 54 mM K+ (experimental) for 1 h at 37°C with monitoring of systemic vital function, hematocrit, arterial blood gases, and determination of cerebrocortical tissue water content.

The mean values for cerebrocapillary diameter were 5% (P<0.05) greater in swollen tissues when compared with comparable mean values determined for controls. The values for minimal intercapillary distance determined from control and experimental animals plotted as relative frequency histograms represented two distinct populations (P<0.0005). The significance of altered capillary morphometric parameters are discussed in relation to K+-induced cerebrocortical swelling.

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Correspondence to E. L. Auen.

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Auen, E.L., Bourke, R.S., Barron, K.D. et al. Alterations in cat cerebrocortical capillary morphometrical parameters following K+-induced cerebrocortical swelling. Acta Neuropathol 47, 175–181 (1979). https://doi.org/10.1007/BF00690544

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Key words

  • Brain capillaries
  • Brain cortex
  • Cat brain
  • Astroglial swelling
  • Brain edema
  • Brain extracellular potassium
  • Morphometry