Advertisement

Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

A morphologic study of opportunistic cerebral toxoplasmosis

  • 29 Accesses

  • 24 Citations

Summary

The morphology of toxoplasma and its interaction with the cellular elements of the brain were studied in a patient who died of extensive cerebral toxoplasmosis superimposed on Hodgkin's disease. The cerebral lesions were devoid of inflammatory cellular response and contained numerous organisms mostly in isolated multiplying forms in neurons, glia and vascular walls. Encysted forms containing multiplying organisms were seen infrequently. Intracellular parasite was identified in normal-appearing neuropil. The mode of multiplication and cyst formation of toxoplasma appeared basically similar to that described under experimental conditions. In addition, a rapid evolution of the cerebral lesions was suggested by computerized tomography. This study suggests that tissue necrosis in human cerebral toxoplasmosis is the result of an increased rate of multiplication and enhanced cellular invasiveness of the parasite most likely related to impaired cellular immunity as has been postulated by clinical and experimental data.

This is a preview of subscription content, log in to check access.

References

  1. Aikawa, M., Komata, Y., Asai, T., Midorikawa, O.: Transmission and scanning electron microscopy of host cell entry by toxoplasma gondii. Am. J. Path.87, 285–290 (1977)

  2. Cook, I.: Isolation of toxoplasma gondii from man. Med. J. Aust1, 850–851 (1965)

  3. Feldman, H. A.: A nationwide serum survey of United States military recruits, 1962. VI. Toxoplasma antibodies. Am. J. Epidemiol.81, 385–391 (1965)

  4. Frenkel, J. K.: Adoptive immunity to intracellular infection. J. Immunol.98, 1309–1319 (1967)

  5. Frenkel, J. K.: Toxoplasmosis. Parasite life cycle, pathology and immunology. In: Hammond, D. M., Long, P. L. (eds.). The Coccidia: Eimeria, Isopora, Toxoplasma, and Related Genera. Baltimore: University Park Press 1973

  6. Frenkel, J. K., Nelson, B. M., Arias-Stella, J.: Immunosuppression and toxoplasmic encephalitis. Clinical and experimental aspects. Human Path.6, 97–111 (1975)

  7. Ghatak, N. R., Poon, T. P., Zimmerman, H. M.: Toxoplasmosis of the central nervous system in the adult: A light and electron microscopic studies of three cases. Arch. Path.89, 337–348 (1970)

  8. Ghatak, N. R., Zimmerman, H. M.: Fine structure of toxoplasma in the human brain. Arch. Path.95, 276–283 (1973)

  9. Jones, T. C., Yeh, S., Hirch, T. G.: The interaction between toxoplasma gondii and mammalian cells. I. Mechanism of entry and intracellular fate of the parasite. J. Exp. Med.136, 1157–1171 (1972)

  10. Lindberg, R. E., Frenkel, J. K.: Toxoplasmosis in nude mice. J. Parasit.63, 219–221 (1977)

  11. Powell, H. C., Gibbs, C. J.: Electron microscopy of toxoplasma gondii in the central nervous system (abstract). J. Neuropath. Exper. Neurol.36, 624 (1977)

  12. Remington, J. S., Cavanaugh, E. N.: Isolation of encysted form of toxoplasma gondii from human skeletal and brain. New Engl. J. Med.273, 1308–1310 (1965)

  13. Ruskin, J., Remington, J. S.: Toxoplasmosis in compromised host. Ann. Int. Med.84, 193–199 (1976)

  14. Sheffield, H. C., Melton, M. L.: The fine structure of toxoplasma gondii. J. Parasit.54, 209–226 (1968)

  15. Townsend, J. J., Wolinsky, J. S., Baringer, R. J., Johnson, P. C.: Acquired toxoplasmosis. A neglected cause of treatable nervous system disease. Arch. Neurol.32, 335–343 (1975)

  16. Yoshizumi, M. O.: Experimental toxoplasma retinitis. A light and electron microscopic study. Arch. Path. Lab. Med.100, 487–490 (1976)

  17. Zimmerman, R. A., Bilanuik, L. T., Shipkin, P. M., Gilden, D. H., Murtagh, F.: Evolution of cerebral abscess: Correlation of clinical features with computed tomography. Neurol. (Minneap.)27, 14–19 (1977)

Download references

Author information

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Ghatak, N.R., Sawyer, D.R. A morphologic study of opportunistic cerebral toxoplasmosis. Acta Neuropathol 42, 217–221 (1978). https://doi.org/10.1007/BF00690360

Download citation

Key words

  • Toxoplasma
  • Cerebral toxoplasmosis
  • Immunosuppression
  • Electron microscopy