Breast Cancer Research and Treatment

, Volume 36, Issue 1, pp 23–34 | Cite as

Recurrence-free survival in breast cancer improved by adjuvant tamoxifen -especially for progesterone receptor positive tumors with a high proliferation

  • Mårten Fernö
  • Bo Baldetorp
  • Pär-Ola Bendahl
  • Åke Borg
  • Sven-Börje Ewers
  • Håkan Olsson
  • Stefan Rydén
  • Helgi Sigurdsson
  • Dick Killander


Although the beneficial effect on breast cancer of adjuvant tamoxifen (TAM) is well established, in the series studied by our group this effect seems to have been restricted to patients with steroid receptor (especially progesterone receptor (PgR)) positive tumors. However, as some patients with PgR-positive tumors manifested recurrence despite adjuvant TAM treatment, the question arose whether some other biological factor(s) could be used to identify these non-responding cases. The level of the S-phase fraction (SPF), as measured by flow cytometry, has been shown to be a useful prognostic marker, prognosis being better in cases where the SPF is low than in those where it is high. The aim of the present study was to relate the prognosis after adjuvant TAM to SPF among patients with PgR-positive tumors.

In the PgR-positive group as a whole, the effect of TAM on prognosis was more pronounced in the high SPF group than in the low SPF group (p = 0.005) the respective decrease in 3 year recurrence rate was from 19 to 43% and from 17 to 9%. Multivariate analysis of the data for the TAM-treated group showed the level of PgR concentration (low positivevs. high positive), lymph node status, and tumor size to be independent predictive factors, but not the level of SPF (i.e. highvs. low). By contrast, among patients not treated with TAM, the SPF was a strong independent prognostic factor.

To sum up, SPF was a strong independent predictor of outcome only for patients receiving no systemic adjuvant therapy, but not in patients receiving adjuvant TAM. Patients with PgR-positive and high S-phase tumors derived more benefit from TAM than patients with PgR-positive and low SPF tumors.

Key words

breast cancer flow cytometry progesterone receptor prognosis proliferation treatment prediction 


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Copyright information

© Kluwer Academic Publishers 1995

Authors and Affiliations

  • Mårten Fernö
    • 1
  • Bo Baldetorp
    • 1
  • Pär-Ola Bendahl
    • 1
  • Åke Borg
    • 1
  • Sven-Börje Ewers
    • 1
  • Håkan Olsson
    • 1
  • Stefan Rydén
    • 2
  • Helgi Sigurdsson
    • 1
  • Dick Killander
    • 1
  1. 1.For the South Sweden Breast Cancer Group: Department of OncologyUniversity HospitalLundSweden
  2. 2.For the South Sweden Breast Cancer Group: Department of SurgeryÄngelholm HospitalÄngelholmSweden

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