Cancer Chemotherapy and Pharmacology

, Volume 27, Issue 2, pp 85–88 | Cite as

Combination salvage chemotherapy using cisplatin and teniposide for patients with refractory germinal testicular tumors

  • Toshihiko Kotake
  • Tsuneharu Miki
Original Articles Teniposide, Refractory Testicular Cancer, Salvage Chemotherapy


Ten patients with refractory germ-cell tumors were treated with a chemotherapy regimen consisting of teniposide and cisplatin (VM-26 and CDDP; P-VM therapy). Three patients (30%) achieved a complete remission (CR) after chemotherapy alone, and another three subjects (30%) attained a CR following chemotherapy and radiation therapy. Three of the six complete responders relapsed but were rendered disease-free by re-salvage therapy. Among the responders, six patients (60%) are alive and remain disease-free after follow-up periods ranging from 18 to 84 months (median, 48 months). However, the toxicity of P-VM therapy was high, with severe myelosuppression being observed in nine patients; nevertheless, all side effects were reversible. We concluded that the P-VM regimen seems to be effective in the treatment of refractory testicular cancers.


Radiation Therapy Germinal Cancer Research Complete Remission Chemotherapy Regimen 
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Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • Toshihiko Kotake
    • 1
  • Tsuneharu Miki
    • 1
  1. 1.Department of UrologyThe Center for Adult DiseasesOsakaJapan

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