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Cancer Chemotherapy and Pharmacology

, Volume 27, Issue 2, pp 85–88 | Cite as

Combination salvage chemotherapy using cisplatin and teniposide for patients with refractory germinal testicular tumors

  • Toshihiko Kotake
  • Tsuneharu Miki
Original Articles Teniposide, Refractory Testicular Cancer, Salvage Chemotherapy

Summary

Ten patients with refractory germ-cell tumors were treated with a chemotherapy regimen consisting of teniposide and cisplatin (VM-26 and CDDP; P-VM therapy). Three patients (30%) achieved a complete remission (CR) after chemotherapy alone, and another three subjects (30%) attained a CR following chemotherapy and radiation therapy. Three of the six complete responders relapsed but were rendered disease-free by re-salvage therapy. Among the responders, six patients (60%) are alive and remain disease-free after follow-up periods ranging from 18 to 84 months (median, 48 months). However, the toxicity of P-VM therapy was high, with severe myelosuppression being observed in nine patients; nevertheless, all side effects were reversible. We concluded that the P-VM regimen seems to be effective in the treatment of refractory testicular cancers.

Keywords

Radiation Therapy Germinal Cancer Research Complete Remission Chemotherapy Regimen 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • Toshihiko Kotake
    • 1
  • Tsuneharu Miki
    • 1
  1. 1.Department of UrologyThe Center for Adult DiseasesOsakaJapan

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