Acute experimental allergic encephalomyelitis (EAE) was induced in Hartley guinea pigs and Lewis rats, which were then treated with synthetic serum thymic factor (FTS). When a dose of 30 μg/100 g body weight of FTS was subcutaneously administered to the animals on days — 1 (before inoculation), 4, 9 and 15 intermittently, clinical symptoms of acute EAE were suppressed. Histopathological evaluation showed that the severity of EAE in FTS-treated guinea pigs was less than in unteated guinea pigs. Immunohistochemical examination showed that the numbers of OX6+, W3/25+, W3/13+ and OX19+ cells in FTS-treated rats were less than in untreated rats and that the number of OX8+ cells in FTS-treated rats was greater than in untreated rats. These findings suggest that FTS induced OX8+ cells in inflammatory lesions and suppressed inflammation in acute EAE.
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Bach JF (1983) Thymulin (FTS-Zn). Clin Immunol Allergy 3:133–156
Bach JF, Dardenne M, Pleau JM, Bach MA (1975) Isolation, biochemical characteristics, and biological activity of a circulating thymic hormone in the mouse and in the human. Ann NY Acad Sci 249:186–210
Bach JF, Dardenne M, Pleau JM, Rosa J (1977) Biochemical characterisation of a serum thymic factor. Nature 266:55–57
Bach JF, Bach MA, Blanot D, Bricas E, Charreire J, Dardenne M, Fournier C, Pleau JM (1978) Thymic serum factor (FTS). Bull Inst Pasteur 76:325–398
Bach MA, Niaudet P (1976) Thymic function in NZB mice. II. Regulatory influence of a circulating thymic factor on antibody production against polyvinylpyrrolidone in NZB mice. J Immunol 117:760–764
Bach MA, Fournier C, Bach JF (1975) Regulation ofϑ-antigen expression by agents altering cyclic AMP level and by thymic factor. Ann NY Acad Sci 249:316–327
Barclay AN (1981) The localization of populations of lymphocytes defined by monoclonal antibodies in rat lymphoid tissues. Immunology 42:593–600
Ben-Nun A, Cohen IR (1982) Experimental autoimmune encephalomyelitis (EAE) mediated by T cell lines: process of selection of lines and characterization of the cells. J Immunol 129:303–308
Bliznakov EG, Wan YP, Chang D, Folkers K (1978) Partial reactivation of impaired immune competence in aged mice by synthetic thymus factors. Biochem Biophys Res Commun 80:631–636
Hickey WF, Gonatas NK (1984) Suppressor T-lymphocytes in the spinal cord of Lewis rats recovered from acute experimental allergic encephalomyelitis. Cell Immunol 85:284–288
Hickey WF, Gonatas NK, Kimura H, Wilson DB (1983) Identification and quantitation of T lymphocyte subsets found in the spinal cord of the Lewis rat during acute experimental allergic encephalomyelitis. J Immunol 131:2805–2809
Lacombe M, Perner F, Dardenne M, Bach JF (1974)Thymectomy in the young pig: effects on the level of circulating thymic hormone. Surgery 76:556–559
Lassmann H (1983) Comparative neuropathology of chronic experimental allergic encephalomyelitis and multiple sclerosis. Springer, Berlin Heidelberg New York Tokyo, pp 1–94
Lassmann H, Vass K, Brunner Ch, Seitelberger F (1986) Characterization of inflammatory infiltrates in experimental allergic encephalomyelitis. Progr Neuropathol 6:33–62
Moore GRW, Traugott U, Stone SH, Raine CS (1985) Dose dependency of MBP-induced demyelination in the guinea pig. J Neurol Sci 70:197–205
Moore GRW, McCarron RM, Traugott U, McFarlin DE, Raine CS (1987) Critical threshold for dose of myelin basic protein in murine autoimmune encephalomyelitis. J Neurol Sci 77:173–184
Nagai Y, Osanai T, Sakakibara K (1982) Intensive suppression of experimental allergic encephalomyelitis (EAE) by serum thymic factor and therapeutic implication for multiple sclerosis. Jpn J Exp Med 52:213–219
Pettinelli CB, McFarlin DE (1981) Adoptive transfer of experimental allergic encephalomyelitis in SJL/J mice after in vitro activation of lymph node cells by myelin basic protein: requirement for Lyt 1+2−T lymphocytes. J Immunol 127:1420–1423
Raine CS (1985) Experimental allergic encephalomyelitis and experimental allergic neuritis. Handb Clin Neurol 47:429–466
Rovenský J, Grimová J, Pekárek J, Korčáková L (1981) The effects of thymosin (fraction V) on adjuvant diseases in rats. Thymus 3:51–53
Schulof RS, Goldstein AL (1981) Thymosins and other thymic hormones. In: Hadden J, Stewart M (eds) The lymphokines Humana Press, Clifton, pp 397–423
Trotter J, Sriram S, Rassenti L, Chou CHJ, Fritz RB, Steinman L (1985) Characterization of T cell lines and clones from SJL/J and (BALB/cxSJL/J)F1 mice specific for myelin basic protein. J Immunol 134:2322–2327
Wiśniewski HM, Keith AB (1977) Chronic relapsing experimental allergic encephalomyelitis: an experimental model of multiple sclerosis. Ann Neurol 1:144–148
Woyciechowska J, Goldstein AL, Driscoll B (1985) Experimental allergic encephalomyelitis in guinea pigs: influence of thymosin fraction V on the disease. J Neuroimmunol 7:215–219
Supported partly by a grant (1987) from the Neuroimmunological Disorders Research Committee, the Ministry of Health and Welfare of Japan
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Kato, S., Nakamura, H. Suppression of acute experimental allergic encephalomyelitis by synthetic serum thymic factor. Acta Neuropathol 75, 337–344 (1988). https://doi.org/10.1007/BF00687786
- Experimental allergic encephalomyelitis
- Serum thymic factor
- Suppressor T cell