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Suppression of acute experimental allergic encephalomyelitis by synthetic serum thymic factor

Clinical, histopathological, and immunohistochemical studies

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Summary

Acute experimental allergic encephalomyelitis (EAE) was induced in Hartley guinea pigs and Lewis rats, which were then treated with synthetic serum thymic factor (FTS). When a dose of 30 μg/100 g body weight of FTS was subcutaneously administered to the animals on days — 1 (before inoculation), 4, 9 and 15 intermittently, clinical symptoms of acute EAE were suppressed. Histopathological evaluation showed that the severity of EAE in FTS-treated guinea pigs was less than in unteated guinea pigs. Immunohistochemical examination showed that the numbers of OX6+, W3/25+, W3/13+ and OX19+ cells in FTS-treated rats were less than in untreated rats and that the number of OX8+ cells in FTS-treated rats was greater than in untreated rats. These findings suggest that FTS induced OX8+ cells in inflammatory lesions and suppressed inflammation in acute EAE.

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Author information

Correspondence to S. Kato.

Additional information

Supported partly by a grant (1987) from the Neuroimmunological Disorders Research Committee, the Ministry of Health and Welfare of Japan

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Kato, S., Nakamura, H. Suppression of acute experimental allergic encephalomyelitis by synthetic serum thymic factor. Acta Neuropathol 75, 337–344 (1988). https://doi.org/10.1007/BF00687786

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Key words

  • Experimental allergic encephalomyelitis
  • Serum thymic factor
  • Suppressor T cell
  • Immunohistochemistry