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Alterations of the Z-lines and I-band myofilaments in human skeletal muscle

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Loss of I-band myofilaments and Z-line material is described in three different pathological conditions; namely, dystrophia myotonica, sub-acute combined degeneration of the spinal cord and amyotrophic lateral sclerosis. In the case of amyotrophic lateral sclerosis hypertrophy of the Z-line is also described. A possible cyclical alteration in the Z-line in response to, so far unknown, pathological stimuli is suggested and in conjunction with this possible loss of I-band myofilaments.


Verlust der I-Band-Myofilamente und des Materials im Z-Streifen werden bei drei verschiedenen pathologischen Zuständen beschrieben. dystrophischer Myotonie, subakuter spinaler Strangdegeneration und myatrophischer Lateralsklerose. Im Falle einer myatrophischen lateralsklerose wird auch eine Hypertrophie des Z-Streifens beschrieben. Es wird eine mögliche cyclische Alteration des Z-Streifens als Reaktion auf verschiedene, bisher unbekannte pathologische Reize und in Verbindung damit ein Verlust der Myofilamente des I-Bandes vermutet.

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Johnson, A.G. Alterations of the Z-lines and I-band myofilaments in human skeletal muscle. Acta Neuropathol 12, 218–226 (1969). https://doi.org/10.1007/BF00687646

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  • Muscle
  • Actin
  • Z-Line
  • Myofibril
  • Loss of Myofilaments