Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

Folliculo-stellate cell adenoma of the pituitary

A light- and electron-microscopic study

  • 31 Accesses

  • 17 Citations


An unusual tumor of the pituitary gland is reported. The most characteristic finding of the present tumor was the presence of numerous “colloid” and mucoid secretions. The cells were stellate in shape and there were intra- or intercellular lumina which were lined by many microvilli and occasional cilia. There were also large accumulations of 10 nm filaments in their cytoplasm. Junctional devices were well formed at the points of mutual contact of these cells. They thus correspond to fetal follicular cells of the anterior pituitary lobe. For this reason, “folliculo-stellate cell adenoma of the pituitary” would best characterize this hitherto undescribed neoplasm.

This is a preview of subscription content, log in to check access.


  1. Bergland RM, Torack RM (1969) An ultrastructural study of follicular cells in the human anterior pituitary. Am J Pathol 57:273–297

  2. Fukuda T (1973) Agranular stellate cells (so-called follicular cells) in human fetal and adult adenohypophysis and in pituitary adenoma. Virchows Arch [Pathol Anat] 359:19–30

  3. Kepes J (1978) Transitional cell tumor of the pituitary gland developing from a Rathke's cleft cyst. Cancer 41:337–343

  4. Kovacs K, Horuth E, Ryan N, Ezrin C (1980) Null cell adenoma of the human pituitary. Virchows Arch [Pathol Anat] 387:165–174

  5. Lawzewitsch I, Dickmann GH, Amezual L, Pardal C (1972) Cytological and ultrastructural characterization of the human pituitary. Acta Anat (Basel) 81:286–316

  6. Nakane PK (1970) Classification of anterior pituitary cell types with immunoenzyme histochemistry. J Histochem Cytochem 18:9–20

  7. Racadot J, Vila-Porcile E, Olivier L, Peillon F (1975) Electron microscopy of pituitary tumor. Prog Neurol Surg (Basel) 6:95–141

  8. Yoshimura F, Soji T, Sato S, Yokoyama M (1977) Development and differentiation of rat pituitary follicular cells under normal and some experimental conditions with special reference to an interpretation of renewal cell system. Endocrinol Jpn 24:435–449

Download references

Author information

Correspondence to S. Yagishita.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Yagishita, S., Itoh, Y., Nakazima, S. et al. Folliculo-stellate cell adenoma of the pituitary. Acta Neuropathol 62, 340–344 (1984). https://doi.org/10.1007/BF00687617

Download citation

Key words

  • Pituitary gland
  • Tumor
  • Folliculo-stellate
  • Cell adenoma