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In vitro culture observations on neurinoma induced experimentally in the rat by ethylnitrosourea

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Five neurinomas of the Vth cranial nerve, produced experimentally in rats by ethylnitrosourea, were cultivatedin vitro: they show a great resemblance with the human neurinomas. It must be emphasized that the resemblance is evident also in cultures of tumours which are characterized histologically by poor differentiation and by high invasiveness.

The morphological and histochemical characteristics are described. In one case a mixed cell population developed in the same culture, with a neurinomatous and an oligodendroglial features. This finding is discussed in relation to tumour differentiation, regression and association with oligodendrogliomas. Particular attention is paid to the possibility of “Gitterzellen” transformation on the grounds of their morphological and histochemical behaviour.

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The research was partially supported by the Italian National Council for Research (CNR), Rome.

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Fornatto, L., Schiffer, D. In vitro culture observations on neurinoma induced experimentally in the rat by ethylnitrosourea. Acta Neuropathol 20, 199–206 (1972). https://doi.org/10.1007/BF00686901

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Key words

  • Neurinoma
  • Ethylnitrosourea
  • Rat Tissue culture
  • Histology
  • Histochemistry