The stability of cisplatin (DDP) solutions (1 and 1.6 mg/ml in saline-mannitol) in plastic infusion bags was studied for up to 14 days at 25° C, 37° C and 60° C. Small changes in the solution were observed, but no evidence of any decomposition product was seen. Some precipitation of DDP was seen in the 1.6-mg/ml solution at the lower temperatures. Fluid loss from the bags was significant at the higher temperatures.
This is a preview of subscription content, log in to check access.
Buy single article
Instant access to the full article PDF.
Price includes VAT for USA
Subscribe to journal
Immediate online access to all issues from 2019. Subscription will auto renew annually.
This is the net price. Taxes to be calculated in checkout.
Baserga R (1981) The cell cycle. N Engl J Med 304: 453
Bresciani F, Paoluzi R, Benassi M, Nervi C, Casale C, Ziparo E (1974) Cell kinetics and growth of squamous cell carcinomas in man. Cancer Res 34: 2405
De Conti RC, Toftness BR, Lange RC, Creasey WA (1973) Clinical and pharmacological studies withcis-diamminedichloroplatinum(II). Cancer Res 33: 1310
Legha SS, Benjamin RS, Mackay B, Yap HY, Wallace S, Ewer M, Blumenschein GR, Freireich EJ (1982) Adriamycin therapy by continuous intravenous infusion in patients with metastatic breast disease. Cancer 49: 1762
Lokich J, Bothe A, Zipoli T, Green R, Sonneborn H, Paul S, Philips D (1983) Constant infusion schedule for Adriamycin: a phase I–II clinical trial of a 30-day schedule by ambulatory pump delivery system. J Clin Oncol 1: 24
Ribaud P, Gouveia J, Bonnay M, Mathe G (1981) Clinical pharmacology and pharmacokinetics of cis-platinum and analogues. Cancer Treat Rep 65 [Suppl 3]: 97
Vogelzang NJ (1984) Continuous infusion therapy. J Clin Oncol 2: 1289
Supported by the Cancer Research Compaign
About this article
Cite this article
Hrubiško, M., Mc Gown, A.T., Prendiville, J.A. et al. Suitability of cisplatin solutions for 14-day continuous infusion by ambulatory pump. Cancer Chemother. Pharmacol. 29, 252–255 (1992). https://doi.org/10.1007/BF00686261
- Cancer Research
- Continuous Infusion
- Decomposition Product
- Fluid Loss
- Plastic Infusion