Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

Suitability of cisplatin solutions for 14-day continuous infusion by ambulatory pump


The stability of cisplatin (DDP) solutions (1 and 1.6 mg/ml in saline-mannitol) in plastic infusion bags was studied for up to 14 days at 25° C, 37° C and 60° C. Small changes in the solution were observed, but no evidence of any decomposition product was seen. Some precipitation of DDP was seen in the 1.6-mg/ml solution at the lower temperatures. Fluid loss from the bags was significant at the higher temperatures.

This is a preview of subscription content, log in to check access.


  1. 1.

    Baserga R (1981) The cell cycle. N Engl J Med 304: 453

  2. 2.

    Bresciani F, Paoluzi R, Benassi M, Nervi C, Casale C, Ziparo E (1974) Cell kinetics and growth of squamous cell carcinomas in man. Cancer Res 34: 2405

  3. 3.

    De Conti RC, Toftness BR, Lange RC, Creasey WA (1973) Clinical and pharmacological studies withcis-diamminedichloroplatinum(II). Cancer Res 33: 1310

  4. 4.

    Legha SS, Benjamin RS, Mackay B, Yap HY, Wallace S, Ewer M, Blumenschein GR, Freireich EJ (1982) Adriamycin therapy by continuous intravenous infusion in patients with metastatic breast disease. Cancer 49: 1762

  5. 5.

    Lokich J, Bothe A, Zipoli T, Green R, Sonneborn H, Paul S, Philips D (1983) Constant infusion schedule for Adriamycin: a phase I–II clinical trial of a 30-day schedule by ambulatory pump delivery system. J Clin Oncol 1: 24

  6. 6.

    Ribaud P, Gouveia J, Bonnay M, Mathe G (1981) Clinical pharmacology and pharmacokinetics of cis-platinum and analogues. Cancer Treat Rep 65 [Suppl 3]: 97

  7. 7.

    Vogelzang NJ (1984) Continuous infusion therapy. J Clin Oncol 2: 1289

Download references

Author information

Additional information

Supported by the Cancer Research Compaign

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Hrubiško, M., Mc Gown, A.T., Prendiville, J.A. et al. Suitability of cisplatin solutions for 14-day continuous infusion by ambulatory pump. Cancer Chemother. Pharmacol. 29, 252–255 (1992). https://doi.org/10.1007/BF00686261

Download citation


  • Cancer Research
  • Continuous Infusion
  • Decomposition Product
  • Fluid Loss
  • Plastic Infusion