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Suitability of cisplatin solutions for 14-day continuous infusion by ambulatory pump

Summary

The stability of cisplatin (DDP) solutions (1 and 1.6 mg/ml in saline-mannitol) in plastic infusion bags was studied for up to 14 days at 25° C, 37° C and 60° C. Small changes in the solution were observed, but no evidence of any decomposition product was seen. Some precipitation of DDP was seen in the 1.6-mg/ml solution at the lower temperatures. Fluid loss from the bags was significant at the higher temperatures.

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Supported by the Cancer Research Compaign

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Hrubiško, M., Mc Gown, A.T., Prendiville, J.A. et al. Suitability of cisplatin solutions for 14-day continuous infusion by ambulatory pump. Cancer Chemother. Pharmacol. 29, 252–255 (1992). https://doi.org/10.1007/BF00686261

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Keywords

  • Cancer Research
  • Continuous Infusion
  • Decomposition Product
  • Fluid Loss
  • Plastic Infusion