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An autopsy case of dementia and parkinsonism with severe degeneration exclusively in the substantia nigra

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We have recently encountered a patient with progressive dementia and parkinsonism beginning at the age of 68 years and developing for 2 years. Pathological examination revealed severe degeneration exclusively in the substantia nigra with absence of Lewy bodies and neurofibrillary changes. The features of this case are reported and discussed.

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Correspondence to K. Oyanagi.

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Oyanagi, K., Nakashima, S., Ikuta, F. et al. An autopsy case of dementia and parkinsonism with severe degeneration exclusively in the substantia nigra. Acta Neuropathol 70, 190–192 (1986). https://doi.org/10.1007/BF00686071

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Key words

  • Dementia
  • Parkinsonism
  • Substantia nigra