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Enzyme histochemical studies of senile plaques and the plaque-like degeneration of arteries and capillaries (Scholz)

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Enzyme histochemical studies, of senile plaques and the plaque-like degeneration of arteries and capillaries (Scholz), were carried out on four brains of patients senile dementia. The NAD-diaphorese activity of the plaques increased, especially in their peripheral zones whereas the central cores showed no enzyme activity. The acid phosphatase activity of senile plaques increased markedly throughout. NAD-d and acid-ph activity in glia cells in the surrounding tissue of the plaques increased markedly. The plaques with a few exceptions showed no acetylcholinesterase activity. The plaque-like degeneration of arteries and capillaries like the central cores of plaques generally showed no NAD-d activity. Acid-ph activity in the degenerated arteries was very weak, suggesting independent amyloid deposition there. Similarity of electronmicroscopic structural and enzymatic findings in the plaques and in Wallerian degeneration (Suzuki and Terry, 1967) and the independent deposition of amyloid in the plaque-like degenerated arteries in the brain, as well as in those of internal organs, suggest that the plaques are formed by severance of neuronal continuity, by the deposition of amyloid, and that amyloid deposition is important in the pathogenesis of senile dementia.


Enzymhistochemische Untersuchungen an senilen Plaques und an drusiger Entartung der Arterien und Capillaren (Scholz) werden an Hand von vier Gehirnen senil Dementer ausgeführt. Die NAD-d-Aktivität der Plaques ist besonders an ihrer Peripherie gesteigert; jedoch zeigen die Kerne der Plaques keine NAD-d-Aktivität. Die saure Phosphatase-Aktivität der Plaques ist im ganzen auffallend gesteigert. Die NAD-d und saure ph-Aktivität der Gliazellen ist in der Umgebung des Plaques gesteigert. Die Plaques zeigen mit wenigen Ausnahmen keine Acetylcholinesterase-Aktivität. Die drusige Entartung der Arterien und Capillaren zeigt ebenso wie die Kerne der Plaques keine NAD-d-Aktivität. Die saure ph-Aktivität der degenerierten Wände der Arterien ist sehr schwach, was auf die selbständige Ablagerung von Amyolid hinweist. Aus der Ähnlichkeit der strukturellen und enzymatischen Befunde der Plaques mit denjenigen der Wallerschen Degenerationen in elektronenmikroskopischen Untersuchungen, und aus der selbständigen Natur der Amyloidablagerung an den drusig entarteten Wänden der Arterien im Gehirn sowie in den Körperorganen zieht der Autor den Schluß, daß die Plaques in der Gehirnrinde in der Folge von Kompression der Neuronenfortsätze durch Amyloidablagerungen gebildet werden und daß die Amyloidablagerungen in der Pathogenese der senile Dementia von Wichtigkeit sind.

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Ishii, T. Enzyme histochemical studies of senile plaques and the plaque-like degeneration of arteries and capillaries (Scholz). Acta Neuropathol 14, 250–260 (1969). https://doi.org/10.1007/BF00685304

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  • Senile Dementia
  • Amyloid
  • Enzyme Histochemistry
  • Senile Plaque
  • Plaque-Like Degeneration (Scholz)