Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

Experimental cerebral ischemia in Mongolian gerbils

III. Behaviour of the blood-brain barrier

  • 45 Accesses

  • 127 Citations

Summary

The behaviour of the BBB in cerebral ischemia was studied in symptompositive Mongolian gerbils subjected to left common carotid artery occlusion using Evans Blue dye as indicator of BBB injury. The BBB damage was demonstrable grossly by the presence of areas of blue discoloration, and microscopically by the presence of a bright red fluorescent tracer, localized mostly in the neurons.

The survey of various groups of animals revealed a direct relationship between the incidence and time of appearance of the BBB lesions and the duration of the ischemic occlusion. This relationship can be interpreted as another example of the previously described “maturation” phenomenon.

A relatively late occurrence of the BBB injury in cerebral ischemia, at the time when the affected brain tissue shows severe, edematous histopathologic changes indicates that the brain edema, as the main complication of ischemia, could be regarded as being primarily of the cytotoxic type.

This is a preview of subscription content, log in to check access.

References

  1. Broman, T.: The permeability of the cerebrospinal vessels in normal and pathological conditions. Copenhagen:Einar Munckgaard 1949

  2. Denny-Brown, D., Meyer, J. S.: The cerebral collateral circulation. 2. Production of cerebral infarction by ischemic anoxia and its reversibility in early stages. Neurology (Minneap.)7, 567–579 (1957)

  3. Hossmann, K.-A., Olsson, Y.: The effect of transient cerebral ischemia on the vascular permeability to protein tracers. Acta neuropath. (Berl.)18, 103–112 (1971)

  4. Ito, U., Spatz, M., Walker, J. T., Jr., Klatzo, I.: Experimental cerebral ischemia in Mongolian gerbils. I. Light microscopic observations. Acta neuropath. (Berl.) (in press)

  5. Kahn, K.: The natural course of experimental cerebral infarction in the gerbil. Neurology (Minneap.)22, 510–516 (1972)

  6. Klatzo, I.: Presidential address: Neuropathological aspects of brain edema. J.Neuropath. exp. Neurol.26, 1–13 (1967)

  7. Meyer, J. S.: Localized changes in properties of the blood and effects of anticoagulant drugs in experimental cerebral infarction. New Engl. J. Med.258, 151–159 (1958)

  8. Mršulja, B. B., Mršulja, B. J., Ito, U., Walker, J. T., Jr., Spatz, M., Klatzo, I.: Experimental cerebral ischemia in Mongolian gerbils. II. Changes in carbohydrates. Acta neuropath. (Berl.) (in press)

  9. Olsson, Y., Crowell, R. M., Klatzo, I.: The blood-brain barrier to protein tracers in focal cerebral ischemia and infaction caused by occlusion of the middle cerebral artery. Acta neuropath. (Berl.)18, 89–102 (1971)

  10. Plum, F., Posner, J. B., Alvord, E. C.: Edema and necrosis in experimental cerebral infarction. Arch. Neurol. (Chic.)9, 563–570 (1963)

  11. Steinwall, O., Klatzo, I.:Selective vulnerability of the blood-brain barrier in chemically induced lesions. J. Neuropath. exp. Neurol.25, 542–559 (1966)

Download references

Author information

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Ito, U., Go, K.G., Walker, J.T. et al. Experimental cerebral ischemia in Mongolian gerbils. Acta Neuropathol 34, 1–6 (1976). https://doi.org/10.1007/BF00684938

Download citation

Key words

  • Cerebral ischemia
  • Blood-brain barrier
  • Mongolian gerbils