The ethanolic phosphotungstic acid technique of Bloom and Aghajanian has been applied to formalin-fixed neuropathological specimens. The staining reactions of various normal organelles were studied as well as a number of pathological alterations including Alzheimer neurofibrillary tangles, eosinophilic rod-like structures, corpora amylacea, lamellar bodies and honeycomb-like structures in the axoplasm.
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Hirano, A., Dembitzer, H.M. & Zimmerman, H.M. The fine structure of phosphotungstic acid stained neuropathologic tissue. Acta Neuropathol 26, 265–272 (1973). https://doi.org/10.1007/BF00684437
- Alzheimer Neurofibrillary Tangles
- Electron Microscope
- Eosinophilic Rod-like Structures
- Phosphotungstic Acid