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The fine structure of phosphotungstic acid stained neuropathologic tissue


The ethanolic phosphotungstic acid technique of Bloom and Aghajanian has been applied to formalin-fixed neuropathological specimens. The staining reactions of various normal organelles were studied as well as a number of pathological alterations including Alzheimer neurofibrillary tangles, eosinophilic rod-like structures, corpora amylacea, lamellar bodies and honeycomb-like structures in the axoplasm.

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Hirano, A., Dembitzer, H.M. & Zimmerman, H.M. The fine structure of phosphotungstic acid stained neuropathologic tissue. Acta Neuropathol 26, 265–272 (1973).

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Key words

  • Alzheimer Neurofibrillary Tangles
  • Electron Microscope
  • Eosinophilic Rod-like Structures
  • Phosphotungstic Acid