We investigate the kinetics of refolding of a catalytic RNA species along a folding pathway which starts at a biologically active structure and ends in the most stable structure, or global free energy minimum. The RNA species studied is not a purely informational molecule, since it is splicedin vivo. We show that the kinetic barriers involved in the relaxation of the active structure are considerably larger than those of a purely informational RNA. Our results attempt at establishing a kinetic criterion to distinguish between a catalytic and a coding RNA species on the basis of their folding.
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Fernández, A. Structural organization of an RNA catalyst with the random energy model as a reference frame. Int J Theor Phys 31, 983–993 (1992). https://doi.org/10.1007/BF00675089
- Free Energy
- Quantum Field Theory
- Reference Frame
- Energy Minimum
- Structural Organization