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Structural organization of an RNA catalyst with the random energy model as a reference frame

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Abstract

We investigate the kinetics of refolding of a catalytic RNA species along a folding pathway which starts at a biologically active structure and ends in the most stable structure, or global free energy minimum. The RNA species studied is not a purely informational molecule, since it is splicedin vivo. We show that the kinetic barriers involved in the relaxation of the active structure are considerably larger than those of a purely informational RNA. Our results attempt at establishing a kinetic criterion to distinguish between a catalytic and a coding RNA species on the basis of their folding.

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References

  1. Cech, T. R. (1988).Gene,73, 259.

  2. Inoue, T., Sullivan, F. X., and Cech, T. R. (1985).Cell,43, 431.

  3. Davies, R. W., Waring, R. B., Ray, J. A., Brown, T. A., and Scazzocchio, C. (1982).Nature,300, 719.

  4. Fernández, A. (1990).Physical Review Letters,64, 2328.

  5. Fernández, A. (1989).European Journal of Biochemistry,182, 161.

  6. Anshelevich, V. V., Vologodskii, V. A., Lukashin, V., and Frank-Kamenetskii, M. D. (1984).Biopolymers,23, 39.

  7. Pleij, C. W., Rietveld, K., and Bosch, L. (1985).Nucleic Acids Research,13, 1717.

  8. Groebe, D. R., and Uhlenbeck, O. C. (1988).Nucleic Acids Research,16, 11725.

  9. Turner, D. H., Sugimoto, N., and Freier, F. M. (1988).Annual Reviews of Biophysics and Biophysical Chemistry,17, 167.

  10. Puglisi, J. D., Wyatt, J. R., and Tinoco, I. (1988).Nature,331, 283.

  11. Lazowska, J., Jacq, C., and Slonimski, P. P. (1980).Cell,22, 333.

  12. Burke, J. M. (1988).Gene,73, 273.

  13. Fernández, A., and Shakhnovich, E. I. (1990).Physical Review A-Rapid Communications,42, 36577.

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Fernández, A. Structural organization of an RNA catalyst with the random energy model as a reference frame. Int J Theor Phys 31, 983–993 (1992). https://doi.org/10.1007/BF00675089

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Keywords

  • Free Energy
  • Quantum Field Theory
  • Reference Frame
  • Energy Minimum
  • Structural Organization