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Muttermundseröffnung und Relaxin

Relaxin and cervical dilatation during parturition

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Summary

Relaxin concentrations during pregnancy and parturition were measured in tissue specimens of the uterine cervix of 27 women in childbearing age.

During pregnancy relaxin levels increase from 0.4 guinea pig unit (GPU) to 0.94 GPU/mg soluble tissue protein. Already during parturition (0.41 GPU) and immediately post partum (0.39 GPU) the hormone concentrations have dropped back to normal.

It appears that the biochemical changes which occur in the connective tissue of the uterine cervix during pregnancy and parturition are influenced by relaxin.

Experimental animals were taken to show if relaxin acts by activation of collagenolytic enzymes. In the mouse a rise in the activity of collagen-peptidase and of the inhibitor of collagen-peptidase in plasma was found after subcutaneous injections of relaxin.

The addition of human cervical tissue extracts resulted in an increase of enzyme-activation (even higher than could be expected of the hormone concentrations of the individual extracts).

The highest levels of the enzyme were found after injections of extracts from cervical tissue specimens of parturient women.

Zusammenfassung

An Gewebsproben der Cervix uteri von 27 Frauen im geschlechtsreifen Alter wurde der Relaxingehalt während Schwangerschaft und Geburt untersucht.

Während der Schwangerschaft steigt der Gehalt an Relaxin von 0,40 GPU auf 0,94 GPU/mg lösliches Gewebsprotein an. Bereits unter der Geburt (0,41 GPU) und unmittelbar post partum (0,39 GPU) sind die Spiegel wieder auf den Normalwert abgefallen.

Die während Schwangerschaft und Geburt ablaufenden biochemischen Veränderungen im kollagenen Bindegewebe der Cervix uteri scheinen vom Relaxin beeinflußt zu werden.

Ob das Hormon dabei über eine Aktivierung der kollagenabbauenden Enzyme wirkt, sollte in Tierversuchen geklärt werden. Nach subcutaner Injektion von Relaxin stiegen die Serumaktivitäten der Kollagen-Peptidase und des Kollagen-Peptidase-Inhibitors bei der Maus an.

Die Gabe von Extrakten aus menschlichem Cervixgewebe führte zu einer noch stärkeren Enzymaktivierung (stärker als nach dem Relaxingehalt der einzelnen Extrakte zu erwarten war).

Die höchsten Enzymspiegel fanden sich nach Verabreichung von Extrakten, die von sub partu entferntem Cervixgewebe stammten.

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Maillot, K.v., Weiß, M., Nagelschmidt, M. et al. Muttermundseröffnung und Relaxin. Arch. Gynak. 223, 323–331 (1977). https://doi.org/10.1007/BF00667371

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Key words

  • Relaxin
  • Cervical dilatation during parturition
  • Cervical tissue

Schlüsselwörter

  • Relaxin
  • Muttermundseröffnung
  • Cervixgewebe