Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

The design and synthesis of a family of multimolecular host-guest inclusion complexes


The discovery thatexo-2,exo-6-dihydroxy-2,6-dimethylbicyclo [3.3.1]nonane (2) forms novel multimolecular canal-type inclusion complexes has led to a systematic study of related molecular structures. This synthetic programme has shown that diol (2) is the prototype of a family of host diols all with the same crystallographic space groupP3121, but with distinctly different canal shapes and dimensions. The structures of the first four members of this new family of hosts are described and contrasted.

This is a preview of subscription content, log in to check access.

References and notes

  1. 1

    R. Bishop and I. G. Dance:J. Chem. Soc., Chem. Commun., 992 (1979).

  2. 2

    D. D. MacNicol, J. J. Kendrick and D. R. Wilson:Chem. Soc. Rev.,7, 65 (1978).

  3. 3

    L. Mandelcorn (ed.):Non-Stoichiometric Compounds, Academic Press, New York, (1964).

  4. 4

    For recent reviews in these areas see: J. L. Atwood, J. E. D. Davies and D. D. MacNicol (eds.):Inclusion Compounds, Vols. 1, 2, and 3, Academic Press, London, (1984).

  5. 5

    R. Bishop, S. Choudhury and I. G. Dance:J. Chem. Soc., Perkin Trans. II, 1159, (1982).

  6. 6

    J. Janku and S. Landa:Coll. Czech. Chem. Commun.,35, 375 (1970).

  7. 7

    B. R. Vogt:Tetrahedron Lett., 1579 (1968).

  8. 8

    R. Bishop, I. G. Dance and S. C. Hawkins:J. Chem. Soc., Chem. Commun., 889 (1983).

  9. 9

    In this paper the termssyn- andanti- are used to define hydroxy substituents relative to the unique ethano or propano bridge present in the diol.

Download references

Author information

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Bishop, R., Dance, I.G., Hawkins, S.C. et al. The design and synthesis of a family of multimolecular host-guest inclusion complexes. Journal of Inclusion Phenomena 2, 75–83 (1984). https://doi.org/10.1007/BF00663241

Download citation


  • Organic Chemistry
  • Molecular Structure
  • Systematic Study
  • Diol
  • Inclusion Complex