Advertisement

Springer Nature is making Coronavirus research free. View research | View latest news | Sign up for updates

Competitive adsorption of fibrinogen and albumin onto polymer microspheres having hydrophilic/hydrophobic heterogeneous surface structures

  • 120 Accesses

  • 20 Citations

Abstract

The competitive adsorption of bovine fibrinogen (BFb) and bovine serum albumin onto polymer microspheres from the mixture solution was examined under various protein-to-microsphere ratios using various homopolymer microspheres and poly(2-hydroxyethyl methacrylate)/polystyrene composite microspheres having heterogeneous surface structures consisting of both hydrophilic and hydrophobic parts. They were produced by emulsifier-free (seeded) emulsion polymerizations. The selective adsorption of BFb was not observed for the homopolymer microspheres, but observed for the composite polymer microspheres having optimum compositions.

This is a preview of subscription content, log in to check access.

References

  1. 1.

    Singer JM, Plotz CM (1956) AM J Med 20:888

  2. 2.

    Grinbnau TCJ, Leuvering JHW, Hell van H (1976) J Chromatog Biomedical Appl 376:565

  3. 3.

    Zsom RLJ (1986) J Colloid Interface Sci 111:434

  4. 4.

    Okubo M, Azuma I, Yamamoto Y (1990) Colloid Polym Sci 268:598

  5. 5.

    Okubo M, Azuma I, Hattori H, Trends in Polym Sci (in press)

  6. 6.

    Okubo M, Azuma I, Hattori H (1992) J Appl Polym Sci 45:245

  7. 7.

    Matsumoto T, Okubo M, Imai T (1975) Kobunshi Ronbunshu 32:229

  8. 8.

    Matsumoto T, Okubo M, Onoe S (1976) Kobunshi Ronbunshu 33:565

  9. 9.

    Matsumoto T, Okubo M, Shibao S (1977) Kobunshi Ronbunshu 34:557

  10. 10.

    Okubo M, Yamada A, Matsumoto T (1981) J Polym Sci Polym Chem 19:1

  11. 11.

    Vijayendran BR, In: Fitch M (ed) Polymer Colloid II. Plenum Press, New York, p 209

  12. 12.

    Okubo M, Yamamoto Y, Kamei S (1989) Colloid Polym Sci 267:861

  13. 13.

    Lensen HGW, Breehaar W, Smolders CA (1986) J Chromatogr Biomedical Appl 376:191

  14. 14.

    Kamei S, Okubo M, Matsumoto T (1987) J Appl Polym Sci 34:1439

  15. 15.

    Fair BD, Jamieson AM (1980) J Colloid Interface Sci 77:525

  16. 16.

    Mihalyi E (1965) Biochim Biophys Acta 102:487

  17. 17.

    Okubo M, Kamei S, Mori K, Matsumoto T (1983) Kobunshi Ronbunshu 40:449

Download references

Author information

Additional information

Part CXXXVIII on the series “Studies on Suspension and Emulsion’

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Okubo, M., Hattori, H. Competitive adsorption of fibrinogen and albumin onto polymer microspheres having hydrophilic/hydrophobic heterogeneous surface structures. Colloid Polym Sci 271, 1157–1164 (1993). https://doi.org/10.1007/BF00657071

Download citation

Key words

  • Polymer emulsion
  • albumin
  • fibrinogen
  • protein
  • adsorption
  • surface hydrophilicity
  • surface heterogeneity
  • microsphere