The competitive adsorption of bovine fibrinogen (BFb) and bovine serum albumin onto polymer microspheres from the mixture solution was examined under various protein-to-microsphere ratios using various homopolymer microspheres and poly(2-hydroxyethyl methacrylate)/polystyrene composite microspheres having heterogeneous surface structures consisting of both hydrophilic and hydrophobic parts. They were produced by emulsifier-free (seeded) emulsion polymerizations. The selective adsorption of BFb was not observed for the homopolymer microspheres, but observed for the composite polymer microspheres having optimum compositions.
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Okubo, M., Hattori, H. Competitive adsorption of fibrinogen and albumin onto polymer microspheres having hydrophilic/hydrophobic heterogeneous surface structures. Colloid Polym Sci 271, 1157–1164 (1993). https://doi.org/10.1007/BF00657071
- Polymer emulsion
- surface hydrophilicity
- surface heterogeneity