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Respiratory responses to stimulation of large fibers afferent from muscle receptors in cats


Experiments were carried out on cats to re-examine the respiratory effects of the stimulation of the large afferent fibers originating in the receptors of the hindlimb muscles. During the contraction of the triceps surae induced by stimulating the ventral roots, pulmonary ventilation increased due to an increase in tidal volume and, usually, in respiratory frequency. An increase in ventilation occurred also during stimulation at group I strength of the central end of the previously cut nerves to the triceps surae (LGS+MG) and to the posterior biceps plus the semitendinosus (PBST) muscles. Appreciable increase in ventilation was seen for stimuli near threshold for group I (Ia+Ib) afferent fibers of the LGS+MG nerves, while stimuli at group Ib strength were needed to produce the same effects when using the PBST nerves. It is concluded that group Ib fibers afferent from muscle receptors play a role in the reflex control of respiration.

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  1. Barnes CD, Pompeiano O (1970) Presynaptic and postsynaptic effects in the monosynaptic reflex pathway to extensor motoneurons following vibration of synergic muscles. Arch Ital Biol 108:259–294

  2. Bessou P, Dejours P, Laporte Y (1959) Effets ventilatoires réflexes de la stimulation de fibres afferentes de grand diamètre, d'origine muscolaire chez le Chat. C R Soc Biol 153:477–481

  3. Bradley K, Eccles JC (1953) Analysis of the fast afferent impulses from thigh muscles. J Physiol (London) 122:462–473

  4. Brock LG, Eccles JC, Rall W (1951) Experimental investigations on the afferent fibers in muscle nerves. Proc R Soc B 138:453–475

  5. Coppin CML, Jack JJB, McIntyre AK (1969) Properties of group I afferent fibres from semitendinosus muscle in the cat. J Physiol (London) 203:45–46P

  6. Coppin CML, Jack JJB, MacLennan CR (1970) A method for the selective electrical activation of tendon organ afferent fibres from the cat soleus muscle. J Physiol (London) 210:18–20P

  7. Decandia M, Gasteiger EL, Mann MD (1971) Excitability changes of extensor motoneurons and primary afferent endings during prolonged stimulation of flexor afferents. Exper Brain Res 12: 150–160

  8. Dejours P (1964) Control of respiration in muscular exercise. In: Fenn WO, Rahan H (ed) Handbook of physiology, Section 3, vol 1. Am Physiol Soc, Washington DC, pp 631–648

  9. Emonet-Dénand F, Jankowska E, Laporte Y (1970) Skeletofusimotor fibres in the rabbit. J Physiol (London) 210:669–680

  10. Fehr HU (1965) Activation by suxamethonium of primary and secondary endings of the same de-efferented muscle spindle during static stretch. J Physiol (London) 178:98–110

  11. Gautier H, Lacaisse A, Dejours P (1969) Ventilatory response to muscle spindle stimulation by succinylcholine in cats. Respir Physiol 7:383–388

  12. Hodgson HJF, Matthews PBC (1968) The ineffectiveness of excitation of the primary endings of the muscle spindle by vibration as a respiratory stimulant in the decerebrated cat. J Physiol (London) 194:555–563

  13. Houk J, Henneman E (1967) Responses of Golgi tendon organs to active contractions of the soleus muscle of the cat. J Neurophysiol 30:466–481

  14. Hunt CC, Kuffler SW (1951) Stretch receptor discharges during muscle contraction. J Physiol (London) 113:298–315

  15. Iaria CT, Jalar UH, Kao FF (1959) The peripheral neural mechanism of exercise hyperpnoea. J Physiol (London) 149:49–50P

  16. Jack JJB (1978) Some methods for selective activation of muscle afferent fibers. In: Porter B (ed) Studies in neurophysiology, Cambridge University Press, pp 155–176

  17. Jack JJB, MacLennan CR (1971) The lack of an electric threshold discrimination between group Ia and group Ib fibers in the nerve to the cat peroneus longus muscle. J Physiol (London) 212:35–36P

  18. Kalia M, Senapati JM, Parida B, Panda A (1972) Reflex increase in ventilation by muscle receptors with nonmedullated fibers (C fibers). J Appl Physiol 32:189–193

  19. Kao FF (1956) Regulation of respiration during muscular activity. Am J Physiol 185:145–151

  20. Koizumi K, Ushiyama J, Brooks C McC (1961) Muscle afferents and activity of respiratory neurons. Am J Physiol 200:679–684

  21. Leitner LM, Dejours P (1971) Reflex increase in ventilation induced by vibrations applied to triceps surae muscle in the cat. Respir Physiol 12:199–204

  22. Leksell L (1945) The action potential and excitatory effects of the small ventral root fibers to skeletal muscle. Acta Physiol Scand 10, Suppl 31:1–84

  23. McCloskey DI, Matthews PBC, Mitchell JH (1972) Absence of appreciable cardiovascular and respiratory responses to muscle vibration. J Physiol (London) 33:623–626

  24. McCloskey DI, Mitchell JH (1972) Reflex cardiovascular and respiratory responses originating in exercising muscle. J Physiol (London) 224:173–186

  25. Matthews BHC (1933) Nerve endings in mammalian muscle. J Physiol (London) 78:1–53

  26. Matthews PBC (1966) The reflex excitation of the soleus muscle of the decerebrated cat caused by vibration applied to its tendon. J Physiol (London) 184:450–472

  27. Matthews PBC, Stein RB (1969) The sensitivity of muscle spindle afferents to small sinusoidal changes in length. J Physiol (London) 200:723–743

  28. Paintal AS (1960) Functional analysis of group III afferent fibers of mammalian muscles. J Physiol (London) 152:250–270

  29. Senapati JM (1966) Effect of stimulation of muscle afferents on ventilation of dogs. J Appl Physiol 21:242–246

  30. Weissman ML, Wasserman K, Huntsman DJ, Whipp BJ (1979) Ventilation and gas exchange during phasic hindlimb exercise in the dog. J Appl Physiol 46:878–884

  31. Weissman ML, Whipp BJ, Huntsman DJ, Wasserman K (1980) Role of neural afferents from working limbs in exercise hyperpnea. J Appl Physiol 49:239–248

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Correspondence to M. Decandia.

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Carcassi, A.M., Concu, A., Decandia, M. et al. Respiratory responses to stimulation of large fibers afferent from muscle receptors in cats. Pflugers Arch. 399, 309–314 (1983).

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Key words

  • Ventilation
  • Muscle contraction
  • Nerve stimulation
  • Group I fibers
  • Respiratory control