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Structural study of the development of ocularity domains using a neural network model

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We present a model for the development of ocularity domains in the visual cortex of mammals during the embryonic stage. We model the thalamo-cortical pathway with a self-organising neural network with two source layers, each of them serving different retinae, and one target layer, where the connections end. The connectivity between the source layers and the target layer is driven by Hebbian learning. In both the source layers and the target layer we assume excitatory lateral signal diffusion between proximal neurons that causes them to be correlated. According to the developmental state being modelled, we do not consider either correlation or anti-correlation between the signals originated in neurons of different retinae. The basic assumptions made are proved to be sufficient to attain a distribution of connections arranged in ocularity domains. The dependence of the geometry of the ocularity domains on the parameters of the model is analysed and a correlation between the width of the signal diffusion and the extent of the domains is found. The generality of the assumptions made allows an easy translation of the model to explain the development of other elements of the sensory nervous system.

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  1. Changeaux JP, Danchin A (1976) Selective stabilization of developing synapses, a mechanism for the specification of neuronal networks. Nature 264:705–712

  2. Goodhill GJ, Willshaw DJ (1994) Elastic net model of ocular dominance: overall stripe pattern and monocular formation. Neural Comput 6:615–621

  3. Haussier AF, Malsburg C von der (1983) Development of retinotopic projections: an analytical treatment. J Theor Biol 2:47–73

  4. Hebb DO (1949) Organization of behavior. Wiley, New York

  5. Horton JC, Dagi LR, McCrane EP, de Monasterio FM (1990) Arrangement of ocular dominance columns in visual cortex. Arch Ophtalmol 108:1025–1031

  6. Hubel DH, Wiesel TN (1963) Receptive fields of cells in striate cortex of very young visually inexperienced kittens. J Neurophysiol 26:994–1002

  7. Kato N (1990) Effects of visual deprivation on the postnatal development of the geniculocortical projection in kittens. Neuroscience 37:101–114

  8. Le Vay S, Hubel DH, Wiesel TN (1975) The pattern of ocular dominance columns in macaque striate cortex revealed by a reduced silver stain. J Comp Neurol 159:559–576

  9. Le Vay S, Stryker MP, Shatz CJ (1978) Ocular dominance columns and their development in layer IV of the cat's visual cortex: a quantitative study. J Comp Neurol 179:223–244

  10. Mastronarde DN (1983) Correlated firing of cat retinal ganglion cells. I. Spontaneously active inputs to X- and Y-cells. J Neurophysiol 49:303–324

  11. Meister M, Wong ROL, Baylor DA, Shatz CJ (1991) Synchronous bursts of action potentials in ganglion cells of the developing mammalian retina. Science 252:939–943

  12. Miller KD, Keller JB, Stryker MP (1989) Ocular dominance column development: analysis and simulation. Science 245:606–615

  13. Stryker MP (1986) The role of neural activity in rearranging connections in the central visual system. In: Ruben RW et al. (ed) The biology of change in otolaryngology. Elsevier, Amsterdam, pp 211–224

  14. Stryker MP, Sherk H, Leventhal AG, Hirsch HVB (1978) Physiological consequences for the cat's visual cortex of effectively restricting early experience with orientation. J Neurophysiol 41:896–909

  15. Wolff JR, Missler M (1992) Synaptic reorganization in developing and adult nervous system. Ann Anat 174:393–403

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Correspondence to M. A. Andrade.

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Andrade, M.A., Morán, F. Structural study of the development of ocularity domains using a neural network model. Biol. Cybern. 74, 243–254 (1996). https://doi.org/10.1007/BF00652225

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  • Neural Network
  • Retina
  • Network Model
  • Visual Cortex
  • Structural Study