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  • First International Symposium on Treatment of Liver Cancer Kobe, Japan, 15–16 November 1987 Session 2: Chemotherapy, Immunotherapy and Radiotherapy
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Treatment of primary liver cancer in Singapore A review of 3200 cases seen between January 1, 1977, and July 31, 1987

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Between January 1977 and July 1987, 3200 patients with hepatocellular carcinoma (HCC) were studied in Singapore. HCC formed 90% of primary liver cancers seen in Singapore and is the second most common fatal malignancy seen in men in the country. Extensive clinical and basic research has defined certain treatment strategies. Of importance is the prompt detection of early nodular tumours, which can be resected. Resection, ‘targetting’ with anticancer drugs and, in selected cases, synchronised direct hepatic irradiation with adriamycin, used as a radiosensitiser, have been promising treatment methods. Biological modifiers, such as interferons and interleukins, offer potential for the future. Preliminary pilot studies suggest that interferons may prevent the development of HCC, but more studies are required. Similarly, selective localisation of anticancer agents with radio-isotopical agents opens opportunities for treatment.

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  1. 1.

    Cancer incidence in singapore 1968–1977 (1983) Shanmugaratnam K, Lee HP, Day NE (eds) International Agency for Research in Cancer, World Health Organisation, pp 1–171

  2. 2.

    Ding JL, Oon CJ (1984) Detection of HBeAg in the lymphocytes of sero-HBeAg negative patients with chronic hepatitis B and primary hepatocellular carcinoma. Cytobios 39: 29

  3. 3.

    Oon CJ (1980) The current status of medical treatment for primary hepatocellular carcinoma. In: Friedman M, Ogawa M, Kisner D (eds) International Congress Series no. 542, Diagnosis and treatment of upper gastrointestinal tumours. Excerpta Medica, Amsterdam, pp 466–482

  4. 4.

    Oon CJ, Friedman MA (1982) Primary hepatocellular carcinoma. Present state of disease and prospects for the future. Cancer Chemother Pharmacol 8: 231–235

  5. 5.

    Oon CJ, Chan SH, Chen F, Chang CH, et al. (1978) Clinical studies in Asian patients with irresectible primary hepatocellular carcinoma treated with adriamycin and prednisolone or combination with 5-fluorouracil, vincristine and prednisolone. Singapore Med J 19 (4): 192–204

  6. 6.

    Report of a WHO scientific meeting on cancer epidemiology and prevention, Singapore 7–10 October, 1985 (1985) Western Pacific Regional Office

  7. 7.

    Wong LYM, Chan SH, Oon CJ, Rauff A (1984) Immunochemical localisation of testosterone in human hepatocellular carcinoma. Histochem J 16: 687–692

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Correspondence to Chong-Jin Oon.

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Oon, C., Rauff, A. & Tan, L.K.A. Treatment of primary liver cancer in Singapore A review of 3200 cases seen between January 1, 1977, and July 31, 1987. Cancer Chemother. Pharmacol. 23, S13–S16 (1989). https://doi.org/10.1007/BF00647231

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  • Carcinoma
  • Pilot Study
  • Interferon
  • Hepatocellular Carcinoma
  • Treatment Strategy