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l-Alanine as an end product of glycolysis inSaccharomyces cerevisiae growing under different hypoxic conditions

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Abstract

Saccharomyces cerevisiae growing under anaerobic or other hypoxic conditions releasesl-alanine into the culture medium as an end product of glycolysis. Although the production of alanine is not as high as that of other fermentation products (ethanol, glycerol, succinic acid), consideration of the pathways leading to alanine in fermenting yeasts indicates that the release of alanine is advantageous to the cellular economy and may be considered as a safety device for excreting reduction equivalents derived from NADPH. No significant changes in the activity of alanine aminotransferase are found in the yeast when grown under different conditions.

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The research was supported by a grant from the Comisión Asesora de Investigación Científica y Téchnica.

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Chico, E., Olavarría, J.S. & de Castro, I.N. l-Alanine as an end product of glycolysis inSaccharomyces cerevisiae growing under different hypoxic conditions. Antonie van Leeuwenhoek 44, 193–201 (1978). https://doi.org/10.1007/BF00643222

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Keywords

  • Glycerol
  • Alanine
  • NADPH
  • Saccharomyces Cerevisiae
  • Hypoxic Condition