Summary
The synaptic connections between histaminergic neurons and substance P (SP) afferents in the caudal magnocellular nucleus (CM) of the hypothalamus were examined using an immunoelectron microscopic mirror method. SP-immunoreactive (SP-IR) terminals made synaptic contacts with the somata, somatic spines and dendrites of histidine decarboxylase immunoreactive (HDC-IR) neurons. This suggests that SP afferents exert monosynaptic influence on the central histaminergic neuronal system.
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Tamiya, R., Hanada, M., Narita, N. et al. Histaminergic neurons receive substance P-ergic inputs in the posterior hypothalamus of the rat. Exp Brain Res 79, 261–265 (1990). https://doi.org/10.1007/BF00608234
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DOI: https://doi.org/10.1007/BF00608234