Use of electron-spin-resonance spectroscopy for studying the conformational states of peptides gramicidin S
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Summary
1. A new method has been proposed for studying the conformational states of peptides in solutions which is based on a consideration of the ESR spectra of their spin-labeled derivatives.
2. The synthesis of derivatives of gramicidin S containing one and two iminoxyl radicals in the2Orn and7Orn side chains has been effected.
3. On the basis of an analysis of the ESR spectra of the compounds obtained at −196°C and 30–62°C, conformations of the side chains of modified ornithine residues in chloroform and ethanol have been proposed.
Keywords
Conformational State Gramicidin Succinimide Radical Fragment OCOCPreview
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