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Pharmacy World and Science

, Volume 18, Issue 2, pp 78–82 | Cite as

Plasticizer extraction of Taxol®-infusion solution from various infusion devices

  • Birgit Maas
  • Christoph Huber
  • Irene Krämer
Practice Reports

Abstract

Taxol® solution extracts the plasticizer DEHP (di(2-ethylhexyl)phthalate) from polyvinyl chloride (PVC) materials. In order to minimize patient exposure to DEHP, Taxol® solutions should be prepared and administered in PVC-free materials. Particulate matter may form in Taxol® infusion solution over time, so that in-line filtration with microporous membranes not greater than 0.22 μm is advisable. The purpose of this study was to evaluate the suitability of various administration- and in-line filter-sets for Taxol® application. The extent of leached DEHP was determined using a Reversed Phase HPLC assay specific for DEHP.

The four tested administration-sets labeled as PVC-free, were all found to be suitable for Taxol® application. The tested standard PVC-lined administration-set should not be used for Taxol® application. Baxter Intermate® LV 250 can be recommended as a disposable infusion device for ambulatory Taxol® application. It can be connected with all the tested filter sets.

Keywords

Paclitaxel Taxol® Compatibility Polyvinyl chloride Plasticizer DEHP 

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Copyright information

© Kluwer Academic Publishers 1996

Authors and Affiliations

  • Birgit Maas
    • 1
  • Christoph Huber
    • 1
  • Irene Krämer
    • 1
  1. 1.ApothekeKlinikum J. Gutenberg UniversitätMainzGermany

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