Chemistry of Natural Compounds

, Volume 18, Issue 6, pp 732–737 | Cite as

Synthesis of biologically active analogs of luliberin with shortened amino acid sequences

  • S. V. Burov
  • S. V. Nikolaev
  • M. P. Smironova
  • G. E. Lupanova
  • Yu. F. Bobrov
  • A. M. Nevolin-Lopatin
  • É. M. Kitaev
Article

Abstract

Two new analogs of the releasing factor of the luteinizing hormone with shortened amino acid sequences have been synthesized by the methods of classical peptide chemistry. The influence of the preparations on the action of chorionic gonadotropin and on the course of processes of ovulation in experimental animals has been studied. The promising nature in this direction of the search for active analogs for luliberin has been shown.

Keywords

Luteinizing Hormone AcOH Chorionic Gonadotropin Isatin Active Analog 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literature cited

  1. 1.
    A. V. Schally, A. Arimura, A. J. Kastin, D. H. Coy, E. J. Coy, J. Vilchez-Martinez, T. W. Redding, R. Geiger, W. König, and H. Wissman, Pure Appl. Chem.,37, 315 (1974).CrossRefGoogle Scholar
  2. 2.
    A. S. Dutta, B. J. A. Furr, M. B. Giles, B. Valcaccia, and A. L. Walpole, Biochem. Biophys. Res. Commun.,81, 382 (1978).CrossRefGoogle Scholar
  3. 3.
    J. A. Vilchez-Martinez, D. H. Coy, A. Arimura, E. J. Coy, J. Hirotsu, and A. V. Schally, Biochem. Biophys. Res. Commun.,59, 1226 (1974).CrossRefGoogle Scholar
  4. 4.
    J. P. Yardley, T. J. Foell, C. W. Beattie, and N. H. Grant, J. Med. Chem.,18, 1244 (1975).CrossRefGoogle Scholar
  5. 5.
    T. Wasiak, J. Humphries, K. Folkers, and C. Y. Bowers, Biochem. Biophys. Res. Commun.,86, 843 (1979).CrossRefGoogle Scholar
  6. 6.
    G. W. Moersch, M. C. Rebstock, E. L. Wittle, F. J. Tinney, E. D. Nicolaides, M. P. Hutt, T. F. Mich, and J. M. Vandenbelt, J. Med. Chem.,22, 935 (1979).CrossRefGoogle Scholar
  7. 7.
    D. H. Coy, I. Mezo, E. Pedroza, M. V. Nekola, J. A. Vilchez-Martinez, P. Piyachurawatana, A. V. Schally, J. Seprodi, and I. Teplan, Proceedings of the 6th American Peptide Symposium (1979), p. 7759.Google Scholar
  8. 8.
    W. König, J. Sandow, and G. Geiger, Peptides. Chemistry, Structure and Biology, Ann Arbor Scientific Publishers, Ann Arbor, Michigan (1975), p. 883.Google Scholar
  9. 9.
    J. Sandow and W. König, J. Endocr.,81, 175 (1979).CrossRefGoogle Scholar
  10. 10.
    S. Shinagawa and M. Fujino, Chem. Pharm. Bull.,23, 229 (1975).CrossRefGoogle Scholar
  11. 11.
    R. F. Fischer and R. R. Whetstone, J. Am. Chem. Soc.,76, 5076 (1954).CrossRefGoogle Scholar
  12. 12.
    W. J. Polglase and E. L. Smith, J. Am. Chem. Soc.,71, 3081 (1949).CrossRefGoogle Scholar
  13. 13.
    K. Hofmann, A. Johl, A. E. Furlenmeier, and H. Kappeler, J. Am. Chem. Soc.,79, 1638 (1957).Google Scholar

Copyright information

© Plenum Publishing Corporation 1983

Authors and Affiliations

  • S. V. Burov
  • S. V. Nikolaev
  • M. P. Smironova
  • G. E. Lupanova
  • Yu. F. Bobrov
  • A. M. Nevolin-Lopatin
  • É. M. Kitaev

There are no affiliations available

Personalised recommendations