Solid-phase synthesis of analogs of the A17–21 fragment of insulin
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The synthesis of the following analogs of the A17–21 fragment of insulin has been effected by the solid-phase method: the hydrobromides of H-Glu-Ala-Tyr-Cys(Bzl)-Asn-OH and of H-Glu-Ala-Phe-Cys(Bzl)-Asn-OH, and also BOC-Ala-Asn-Tyr(Bzl)-Cys(Bzl)-Asn-OH. The possibility of adding to a chloromethylated polymeric support a protected dipeptide with the composition BOC-Cys(Bzl)-Asn-OH has been shown.
KeywordsChloromethylated DMFA CF3COOH Polymeric Support Polymeric Carrier
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