Chemistry of Natural Compounds

, Volume 6, Issue 3, pp 358–359 | Cite as

Synthesis of the heptapeptide of the cyclopeptide moiety of polymixin B

  • E. A. Morozova
  • M. A. Zevail'
Article
  • 24 Downloads

Conclusions

The synthesis of the heptapeptideNɛ-BOC-Nα-pelargonyl-L-lysyl-Nɛ-Z-L-lysyl-D-phenylalanyl-L-leucyl-Nɛ-Z-L-lysyl-Nɛ-Z-L-lysyl-L-threonine, a linear analog of the cyclopeptide part of the antibiotic polymixin B, has been effected (yield 63%). The possibility of using this method for the synthesis of peptides on a polymer support without protecting the hydroxyl group of threonine has been shown.

Keywords

Pelargonic Acid Triethylamine Hydrochloride Diaminobutyric Acid Weakly Acid Reaction Attached Amino Acid 

References

  1. 1.
    W. Hausmann and J. C. Craig, J. Am. Chem. Soc.,76, 4892, 1954.CrossRefGoogle Scholar
  2. 2.
    K. Vogler, R. O. Studer, P. Lanz, W. Lergier, and E. Bohni, Helv. Chim. Acta,48, 1161, 1965.CrossRefGoogle Scholar
  3. 3.
    K. Vogler and R. O. Studer, Exper.,22, 6, 345, 1966.Google Scholar
  4. 4.
    R. B. Merrifield, J. Am. Chem. Soc.,85, 2149, 1963.CrossRefGoogle Scholar
  5. 5.
    K. Hofmann, R. Schmiechen, R. D. Wells, Y. Wolman, and N. Yanaihara, J. Am. Chem. Soc.,87, 1965.CrossRefGoogle Scholar
  6. 6.
    B. Beras and L. Zervas, J. Am. Chem. Soc.,83, 719, 1961.CrossRefGoogle Scholar

Copyright information

© Consultants Bureau 1973

Authors and Affiliations

  • E. A. Morozova
    • 1
  • M. A. Zevail'
    • 1
  1. 1.Moscow State UniversityUSSR

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