Chemistry of Natural Compounds

, Volume 11, Issue 1, pp 45–54 | Cite as

Synthesis and biological properties of bradykinin-potentiating peptides from snake venom

  • G. A. Ravdel'
  • N. N. Monapova
  • N. A. Krit
  • M. P. Filatova
  • Yu. I. Lisunkin
  • V. T. Ivanov
Article
  • 19 Downloads

Summary

A pentapeptide and undecapeptide possessing bradykinin-potentiating action have been synthesized, and they have been subjected to comparative pharmacological investigation.

Keywords

Bradykinin Snake Venom Hypotensive Effect DMFA Benzyl Ester 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literature cited

  1. 1.
    S. H. Ferreira, D. C. Bartelt, and L. J. Greene, Biochemistry,9, 2583 (1970).CrossRefGoogle Scholar
  2. 2.
    M. A. Ondetti, N. J. Williams, E. F. Sabo, J. Plusces, E. R. Weaver, and O. Kocy, Biochemistry,10, 4033 (1971).CrossRefGoogle Scholar
  3. 3.
    H. Kato and T. Suzuki, Experientia,25, 694 (1969).CrossRefGoogle Scholar
  4. 4.
    H. Kato and T. Suzuki, Experientia,26, 1205 (1970).CrossRefGoogle Scholar
  5. 5.
    H. Kato and T. Suzuki, Proc. Jap. Acad.,46, 176 (1970).CrossRefGoogle Scholar
  6. 6.
    H. Kato and T. Suzuki, Biochemistry,10, 972 (1971).CrossRefGoogle Scholar
  7. 7.
    J. M. Stewart, S. H. Ferreira, and L. J. Greene, Biochem. Pharmacol.,20, 1557 (1957).CrossRefGoogle Scholar
  8. 8.
    E. Ueda, Kokuba, H. Akutsu, and Y. Yamamura, Experientia,9, 1020 (1971).CrossRefGoogle Scholar
  9. 9.
    S. L. Engel, T. R. Schaeffer, B. J. Gold, and B. Rubin, Proc. Soc. Exp. Biol. Med.,140, 240 (1972).CrossRefGoogle Scholar
  10. 10.
    L. J. Greene, A. C. M. Comargo, E. M. Krieger, J. M. Stewart, and S. H. Ferreira, Circulation Research,31, Suppl. ii, 62 (1972).Google Scholar
  11. 11.
    Y. S. Barhle, Brit. J. Pharmac.,43, 252 (1971).CrossRefGoogle Scholar
  12. 12.
    Biochem. J.,126, 773 (1972).Google Scholar
  13. 13.
    T. Kimura, H. Kato. S. Sakakibara, and T. Suzuki, Progr. Peptide Res., 261 (1972).Google Scholar
  14. 14.
    R. J. Freer and J. M. Stewart, Ciencia e Cultura,23, 539 (1971).Google Scholar
  15. 15.
    S. H. Ferreira, Brit. J. Pharmac.,24, 163 (1965).Google Scholar
  16. 16.
    G. W. Anderson, J. E. Zimmerman, and F. M. Callahan, J. Amer. Chem. Soc.,86, 1839 (1964).CrossRefGoogle Scholar
  17. 17.
    E. Klieger and H. Gibian, Ann. Chem.,640, 145 (1961).CrossRefGoogle Scholar
  18. 18.
    K. Suzuki, Chem. Pharm. Ball.,14, 909 (1966).CrossRefGoogle Scholar
  19. 19.
    L. A. Shchukina, G. A. Ravdel', M. P. Filatova, E. P. Semkin, and S. N. Krasnova, Khim. Prirodn. Soedin., 124 (1966).Google Scholar

Copyright information

© Plenum Publishing Corporation 1976

Authors and Affiliations

  • G. A. Ravdel'
  • N. N. Monapova
  • N. A. Krit
  • M. P. Filatova
  • Yu. I. Lisunkin
  • V. T. Ivanov

There are no affiliations available

Personalised recommendations