Chemistry of Natural Compounds

, Volume 9, Issue 2, pp 247–250 | Cite as

The solid-phase synthesis and some properties of tetrapeptide hydrazides related to the a13–16 fragment of insulin

  • G. A. Korshunova
  • G. P. Mishin
  • O. M. Vol'pina
  • Yu. P. Shvachkin
Article
  • 19 Downloads

Summary

The following tetrapeptide-hydrazides related to the A13–16 fragment of insulin have been synthesized by the solid-phase method: BOC-Gly-Tyr(Bzl)-GlN-Leu-NHNH2, BOC-Ala-Tyr (Bzl)-GlN-Leu-NHNH2, BOC-Val-Tyr(Bzl)-GlN-Leu-NHNH2, BOC-Phe-Tyr(Bzl)-GlN-Leu-NHNH2, BOC-Leu-Phe-GlN-Leu-NHNH2 and BOC-Phe-Tyr(Bzl)-GlN-Leu-NHNH2. BOC-Leu-Phe-GlN-Leu-Ome has also been obtained as an intermediate. By block condensation using the azide method in solution the following analogs of the A13 21 fragment of insulin have been synthesized: BOC-Gly-Tyr(Bzl-GlN-Leu-Glu-Ala-Tyr-Cys(Bzl)AsN-OH and BOC-Leu-Phe-GlN-Leu-Glu-Ala-Tyr-Cys(Bzl)-AsN-OH.

Keywords

Hydrazine Hydrate Paper Chromatography Vacuum Desiccator Hydrobromide DMFA 

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Copyright information

© Plenum Publishing Corporation 1975

Authors and Affiliations

  • G. A. Korshunova
  • G. P. Mishin
  • O. M. Vol'pina
  • Yu. P. Shvachkin

There are no affiliations available

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