The following tetrapeptide-hydrazides related to the A13–16 fragment of insulin have been synthesized by the solid-phase method: BOC-Gly-Tyr(Bzl)-GlN-Leu-NHNH2, BOC-Ala-Tyr (Bzl)-GlN-Leu-NHNH2, BOC-Val-Tyr(Bzl)-GlN-Leu-NHNH2, BOC-Phe-Tyr(Bzl)-GlN-Leu-NHNH2, BOC-Leu-Phe-GlN-Leu-NHNH2 and BOC-Phe-Tyr(Bzl)-GlN-Leu-NHNH2. BOC-Leu-Phe-GlN-Leu-Ome has also been obtained as an intermediate. By block condensation using the azide method in solution the following analogs of the A13 21 fragment of insulin have been synthesized: BOC-Gly-Tyr(Bzl-GlN-Leu-Glu-Ala-Tyr-Cys(Bzl)AsN-OH and BOC-Leu-Phe-GlN-Leu-Glu-Ala-Tyr-Cys(Bzl)-AsN-OH.
Hydrazine Hydrate Paper Chromatography Vacuum Desiccator Hydrobromide DMFA
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