Advertisement

Archives of Dermatological Research

, Volume 256, Issue 1, pp 13–22 | Cite as

Allgemeiner immunstatus bei patienten mit generalisiertem lichen ruber planus

  • Christa Cerni
  • H. Ebner
  • Eva-Maria Kokoschka
Article

Zusammenfassung

Bei 30 Patienten mit generalisiertem Lichen ruber planus (L.r.pl.) wurden folgende Untersuchungen durchgeführt, um Informationen über den allgemeinen, immunologischen Status zu erhalten:
  1. 1.

    Quantitative Bestimmung der Immunglobuline und Komplementfraktion (β 1C/A)

     
  2. 2.

    Intrakutanteste mit Recall-Antigenen

     
  3. 3.

    Prüfung der percutanen Sensibilisierbarkeit gegen DNCB

     
  4. 4.

    Lymphozytenmigrations- und -transformationstests.

     

Die Auswertung der Untersuchungsresultate ergab keine statistisch signifikanten Unterschiede zwischen Lichen ruber-Patienten und Kontrollgruppe. Dadurch läßt sich die Annahme, daß dem L.r.pl. immunologische Vorgänge zugrunde liegen, nicht entkräften; weitere Studien mit spezifischeren Methoden wären zur Klärung dieser Frage erforderlich.

Immunological investigations in lichen planus patients

Summary

30 patients suffering from generalized lichen planus (= L.p.) have been examined by the following methods in order to obtain more precise information regarding their immune-status:
  1. 1.

    Quantitative determination of immuno-globulins including complement fraction (β 1C/A)

     
  2. 2.

    Intracutaneous tests with recall-antigens

     
  3. 3.

    Investigation of cutaneous sensitivity to DNCB

     
  4. 4.

    Lymphocytemigrationinhibition- and Lymphocytetransformationstests.

     

The results obtained were not statistically significant when comparing the results of this investigation in patients suffering from L.p. with the control group. Therefore, the theory that immunological processes are the basis of these occurences is still under discussion. Further studies applying more specific methods should be conducted in order to clarify this problem.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  1. 1.
    Bizzozero, E., Depaoli, M.: Lichen ruber planus e dermatosi invisibili. Minerva dermat. (Torino)28, 213–215 (1953)Google Scholar
  2. 2.
    Black, M. M.: The pathogenesis of lichen planus. Brit. J. Derm.86, 302–305 (1972)CrossRefGoogle Scholar
  3. 3.
    Black, M. M., Wilson-Jones, E.: The role of the epidermis in the histopathogenesis of lichen planus. Arch. Derm.105, 81–86 (1972)CrossRefGoogle Scholar
  4. 4.
    Boyum, A.: Separation of blood leucocytes, granulocytes and lymphocytes. Tissue Antigens4, 269–271 (1974)CrossRefGoogle Scholar
  5. 5.
    Buckley, W. R.: Lichenoid eruptions following contact dermatitis. Arch. Derm.78, 454–457 (1958)CrossRefGoogle Scholar
  6. 6.
    Buckley, C. E., Dorsey, F. C.: Serum Ig levels through out the lifespan of healthy man. Ann. Intern. Med.75, 673 (1971)CrossRefGoogle Scholar
  7. 7.
    Canizares, O.: Lichen planus-like eruption caused by color developer. Arch. Derm.80, 81–86 (1959)CrossRefGoogle Scholar
  8. 8.
    Cotton, D. W. K., von den Hurk, José, J. M. A., van der Staak, W. B. J. M.: Lichen planus; an inborn error of metabolism. Brit. J. Derm.87, 341–346 (1972)CrossRefGoogle Scholar
  9. 9.
    Depaoli, M.: Su alcuni aspetti palisintometici del lichen ruber planus. Minerva Derm. (Torino)41, 249–257 (1966)Google Scholar
  10. 10.
    Documenta Geigy: Wissenschaftliche Tabellen, 8. Aufl. (1972)Google Scholar
  11. 11.
    Ebner, H., Gebhart, W.: Die Ultrastruktur der Epidermis-Cutis-Grenze beim Lichen ruber planus. Arch. Derm. Forsch.245, 285–294 (1972)CrossRefGoogle Scholar
  12. 12.
    Ebner, H.: Untersuchungen über die celluläre Zusammensetzung des Lichen ruber planus-Infiltrates. Arch. Derm. Forsch.247, 309–318 (1973)CrossRefGoogle Scholar
  13. 13.
    Eilberg, F. R., Morton, D. L.: Immunological reactivity and recurrance following cancer surgery. Cancer25, 362–364 (1970)CrossRefGoogle Scholar
  14. 14.
    Falk, R. E., Zabriskie, J. B.: The capillary technique for measurement of inhibition of cell-mediated immunity. In: Bloom, B. R., Glade, P. R. (eds.), In vitro methods in cell-mediated immunity, p. 301–307, New York: Academic Press 1971CrossRefGoogle Scholar
  15. 15.
    Graciansky, P. de, Boulle, S., Cardot, J.-L.: Lichen plan des muqueuses chez un ouvrier du développement des films en coleur. Bull. Soc. franc. Derm. Syph.67, 439–441 (1960)Google Scholar
  16. 16.
    Hyman, A. B., Berger, R. A.: Lichenoid eruption due to color developer. Arch. Derm.80, 243–244 (1959)CrossRefGoogle Scholar
  17. 17.
    Johansson, S., Bennich, H., Wide, L.: A new class of immunoglobulin in human serum. Immunology14, 265 (1968)PubMedPubMedCentralGoogle Scholar
  18. 18.
    Knudsen, E. A.: Lichen planus-like eruption caused by color developer. The topical action of 3-Methyl-4-Amino-N-diethylanilinemonohydrochloride (CD-2) on the skin. Arch. Derm.89, 357–359 (1964)CrossRefGoogle Scholar
  19. 19.
    Konrad, B.: Atebrin dermatitis. Csl. Derm.34, 175–179 (1959)Google Scholar
  20. 20.
    Kyrle, J.: Histo-Biologie der menschlichen Haut und ihrer Erkrankungen. Berlin: Springer 1925CrossRefGoogle Scholar
  21. 21.
    Lachapelle, J. M., de la Brassine, M.: The proliferation of cells in the dermal infiltrate of lichen planus lesions. Brit. J. Derm.89, 137–141 (1973)CrossRefGoogle Scholar
  22. 22.
    Lever, W. F.: Histopathology of the skin, 4th ed. Philadelphia: J. B. Lippincott Comp. 1967Google Scholar
  23. 23.
    Mancini, G., Carbonara, A. O., Heremans, J. F.: Immunological quantitation of antigens by single radial immundiffusion. Immunochemistry2, 235 (1965)CrossRefGoogle Scholar
  24. 24.
    Mandel, E. H.: Lichen planus-like eruption caused by a colorfilm developer. Arch. Derm.81, 516–519 (1960)CrossRefGoogle Scholar
  25. 25.
    Mittenecker, E.: Planung und statistische Auswertung von Experimenten. 8. Aufl. Wien: Deuticke 1971Google Scholar
  26. 26.
    Paschoud, J. M.: Two cases of lichenoid contact eczema closely resembling Lichen planus. Dermatologica (Basel)127, 99–107 (1963)CrossRefGoogle Scholar
  27. 27.
    Pinkus, H.: Lichenoid tissue reactions. Arch. Derm.107, 840–846 (1973)CrossRefGoogle Scholar
  28. 28.
    Pinkus, H., Mehregan, A. M.: A guide to dermatohistopathology. London: Butterworths 1969Google Scholar
  29. 29.
    Saito, T., Hamada, T.: Lichen ruber planus occuring in a color-film processor. Clin. Derm. (Tokyo)6, 760–769 (1964)Google Scholar
  30. 30.
    Samman, P. D.: Lichen planus and lichenoid eruptions. In: Textbook of Dermatology, ed. by A. Rook, D. S. Wilkinson and F. J. G. Ebling, Ilnd Edition. Blackwell 1972Google Scholar
  31. 31.
    Sarkany, I., Gaylarde, P. M.: The pathogenesis of Lichen planus. Correspondence. Brit. J. Derm.8, 81 (1972)CrossRefGoogle Scholar
  32. 32.
    Saurat, J. H., Gluckman, E., Bussel, A., Didierjean, L., Puissant, A.: The lichen planus-like eruption after bone marrow transplantation. Brit. J. Derm.92, 675–681 (1975)CrossRefGoogle Scholar
  33. 33.
    Stankler, L., Ewen, S. W. B.: The effects of experimental skin damage in patients with lichen planus. A preliminary communication. Brit. J. Derm.90, 25–28 (1974)CrossRefGoogle Scholar
  34. 34.
    Stankler, L.: Deficiency of circulating IgA und IgM in adult patients with lichen planus. Brit. J. Derm.93, 25–27 (1975)CrossRefGoogle Scholar
  35. 35.
    Stüttgen, G.: Lichen ruber und Pityriasis rubra pilaris. In: Handbuch der Haut- und Geschl.-Krankheiten von J. Jadassohn, Band III/1, Berlin-Göttingen-Heidelberg: Springer 1963Google Scholar
  36. 36.
    Tan, R. S.-H., Byron, N. A., Hayes, J. P.: A method of liberating living cells from the dermal infiltrate. Studies on skin reticuloses and lichen planus. Brit. J. Derm.93, 271–276 (1975)CrossRefGoogle Scholar
  37. 37.
    Thyresson, N., Moberger, G.: Cytologic studies in Lichen ruber planus. Acta derm.-venereol. (Stockh.)37, 191–204 (1957)Google Scholar
  38. 38.
    Vilanova, X., Pugol Ribalta, J.: Liquen plano de origen professional. Act. dermo-sifil.54, 597–601 (1963)Google Scholar
  39. 39.
    Wechsler, H. L.: Dermatitis medicamentosa. A Lichen-planus-like eruption due to quinidine. Arch. Derm.69, 741–744 (1954)Google Scholar
  40. 40.
    Wilson, D. J.: Eczematous and pigmentary lichenoid dermatitis: Atypical lichen planus. Arch. Derm.54, 377–396 (1946)CrossRefGoogle Scholar
  41. 41.
    Yamamura, M.: Standardization of lymphocyte transformation to PHA. Clin. Exp. Immunology14, 3, 457 (1973)Google Scholar

Copyright information

© Springer-Verlag 1976

Authors and Affiliations

  • Christa Cerni
    • 1
    • 2
  • H. Ebner
    • 2
  • Eva-Maria Kokoschka
    • 2
  1. 1.Inst. für Krebsforschung der Univ.WienGermany
  2. 2.II. Univ.-HautklinikWienGermany

Personalised recommendations