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European Journal of Pediatrics

, Volume 119, Issue 1, pp 47–52 | Cite as

Chromosomenuntersuchungen bei Bactrim®-behandelten Kindern

  • Erich Gebhart
Article

Zusammenfassung

Bei 10 Kindern wurden vor Beginn und nach Abschluß einer Bactrim®-(Eusaprim®-Therapie Chromosomenuntersuchungen an Lymphocytenkulturen aus dem peripheren Blut durchgeführt. Die Rate chromosomaler Strukturdefekte, insbesondere die Brunchrate, war nach Abschluß der Therapie gegenüber den vor Therapiebeginn beobachteten Werten nicht erhöht.

Chromosome studies in children treated with Bactrim®

Abstract

Chromosome studies were performed in cultures of peripheral blood lymphocytes drawn from 10 children before and after a therapy with Bactrim® (Eusaprim®). No significant difference was found between the rate of structural chromosome aberrations, especially the breakage rate, before and after treatment.

Key words

Chromosome studies Chromosome breakage Bactrim® Eusaprim® Mutagenicity 

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Literatur

  1. Bell, W. R., Whang, J. J., Carbone, P. P., Brecher, G., Block, J. B.: Cytogenetic and morphologic abnormalities in human bone marrow cells during cytosine arabinoside therapy. Blood 27, 771–781 (1966)PubMedGoogle Scholar
  2. Brøgger, A.: Apparently spontaneous chromosome damage in human leukocytes and the nature of chromatid gaps. Humangenetik 13, 1–14 (1971)CrossRefGoogle Scholar
  3. Buckton, K. E., Evans, H. J. (Hrsg.): Methods for the analysis of human chromosome aberrations. WHO (1973)Google Scholar
  4. Chaudhuri, J. P.: On the origin and nature of achromatic lesions. In: Chromosomes today (Hrsg. C. D. Darlington, K. R. Lewis), Bd. 3, S. 147–151. Edinburgh: Oliver and Boyd 1972Google Scholar
  5. Gebhart, E.: The treatment of human chromosomes in vitro: results. In: Chemical mutagenesis in mammals and man (Hrsg. F. Vogel, G. Röhrborn). Berlin-Heidelberg-New York: Springer 1970Google Scholar
  6. Gebhart, E.: Experimentelle Beiträge zum Problem der lokalen Achromasien (Gaps). Humangenetik 13, 98–107 (1971)CrossRefGoogle Scholar
  7. Gebhart, E.: Chromosomenaberrationen bei chemisch belasteten Patienten. Ärztl. Prax. 25, 665–666 (1973a)Google Scholar
  8. Gebhart, E.: Die Gefährdung des menschlichen Erbgutes durch Arzneimittel. Münch. med. Wschr. 115, 1237–1243 (1973b)PubMedGoogle Scholar
  9. Bebhart, E.: Chromosomenuntersuchungen bei Bactrim®-Therapie. Med. Klin. 68, 878–881 (1973c)Google Scholar
  10. Gripenberg, U., Forbes, C.: Extensive cytological damage caused by measles in African children. J. med. Genet. 11, 171–176 (1974)CrossRefGoogle Scholar
  11. Krogh Jensen, M.: Chromosome studies in patients treated with azathioprine and amethopterin. Acta med. scand. 182, 445–455 (1967)CrossRefGoogle Scholar
  12. Krogh Jensen, M.: Effect of azathioprine on the chromosome complement of human bone marrow cells. Int. J. Cancer 5, 147–151 (1970)CrossRefGoogle Scholar
  13. Makino, S., Aya, T.: Cytogenetic studies in leukocyte cultures from patients with some viral diseases and in those infected with HSV. Cytologia 33, 370–396 (1968)CrossRefGoogle Scholar
  14. Nasjleti, C. E., Spencer, H. H.: Chromosome damage and polyploidization induced in human peripheral leucocytes in vivo and in vitro with nitrogen mustard, 6-mercaptopurine, and A 649. Cancer Res. 26, 2437–2443 (1966)PubMedGoogle Scholar
  15. Nichols, W. W.: Interactions between viruses and chromosomes. In: Handbook of molecular cytology (Hrsg. A. Lima-de-Faria). Amsterdam-London: North Holland Publ. Comp. 1969Google Scholar
  16. Pedersen, B.: Chromosome aberrations in blood, bone marrow, and skin from a patient with acute leukemia treated with 6-mercaptopurine. Acta path. microbiol. scand. 61, 261–267 (1964)CrossRefGoogle Scholar
  17. Scheid, W., Traut, H.: On the nature of achromatic lesions (“gaps”) induced by X-rays in chromosomes of Vicia faba. Z. Naturforsch. 26b, 1384–1385 (1971)CrossRefGoogle Scholar
  18. Stevenson, A. C., Clarke, G., Patel, C. R., Hughes, D. T. G.: Chromosomal studies in vivo and in vitro of trimethoprim and sulphamethoxazole (CO-Trimoxazole). Mutat. Res. 17, 255–260 (1973)CrossRefGoogle Scholar

Copyright information

© Springer-Verlag 1975

Authors and Affiliations

  • Erich Gebhart
    • 1
  1. 1.Institut für Humangenetik und Anthropologie der Universität Erlangen-NürnbergErlangenDeutschland

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