Pharmakokinetik der neuen Aminoglykosid-Antibiotica im Innenohr und Ototoxicität
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Pharmacokinetics of the new aminoglycoside-antibiotics in the inner ear and ototoxicity
The pharmacokinetics of the new aminoglycoside-antibiotics are examined in the inner ear fluids of the guinea pig and compared to the pharmacokinetics of these antibiotics in the cerebrospinal fluid as well as in the compartments of the eye. Furthermore these investigations are made in order to compare the ototoxicity of these antibiotics and to test new methods for the treatment of ototoxic damages.