Ätiologische Aspekte der Polyposis nasi et sinuum — vergleichende klinische, morphologische und immunologische Untersuchungen
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Etiological aspects of polyposis nasi et sinuum.—comparative clinical, morphological and immunological investigations
Disorders of the immune system have been discussed as a possible cause of chronic sinusitis, but have up to date not been adequately substantiated.
After the establishment of detailed case histories and clinical findings, samples of mucous membrane obtained by surgery from 50 patients with polyposis nasi et sinuum were examined histomorphologioally with respect to the intensity of edema, and the nature and extent of cellular infiltration. Parallel to this, the humoral immune reaction was determined by quantitative determination of the antibody-producing cells and the level of immunoglobulins in the tissue and serum. Histologically, all the preparations revealed a variety of marked stages of inflammation. The individual regions of mucosa manifested varying degrees of cellular infiltrations by lymphocytes and plasma cells.
An immunological disorder in the form of an immune defect or a hypersensitivity reaction, corresponding to the histomorphological and clinical findings, was demonstrable only in a few individual cases.