Untersuchungen über das Verteilungsmuster immunkompetenter Zellen mit Antikörperreceptoren (B-Zellen) in Tonsillen von Kindern und Jugendlichen
Investigations or the pattern of immunocompetent cells with antibody receptors (B-cells) in tonsils of children and young adults
Viable lymphocytes were isolated from tonsils of about 50 children and young adults. These lymphocytes were incubated with fluoresceinisothiocyanate labeled antibodies against human IgG, IgM and IgA and examined for membranefluorescence.
The obtained pattern of the distribution of cells is visualized in diagrams. The results were analysed in connection with clinical and histological findings and with age groups. We found a wide spreading of different B-cell types. This was most significant in IgM cells when different age groups were compared. Repeated infections appear to produce an increase of IgG and IgA cells.
Polyvalent immunisations including oral polio vaccination are followed by a slight increase of IgM cells.
In histological prooved acute and chronical infected tonsils IgA cells are more frequent than in tonsils with simple hyperplasia.