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Pharmacy World and Science

, Volume 18, Issue 3, pp 109–113 | Cite as

Pharmacokinetics of propylene glycol after rectal administration

  • W. J. Kollöffel
  • L. E. A. Weekers
  • P. B. Goldhoorn
Articles

Abstract

Propylene glycol is an excipient of various pharmaceutical preparations. The pharmacokinetics after rectal administration are studied, followed by a consideration on local and systemic side-effects for a solution of paracetamol in a mixture of propylene glycol and water. After administration of 8.64 g propylene glycol to 10 adults and 173 mg/kg body weight to 4 children, peak concentrations (Cmax) of 119 mg/l and 171 mg/l respectively were reached (tmax) after 1.5 hr and 1.0 hr. The average terminal half-lives (t1/2) in adults and children were respectively 2.8 hr and 2.6 hr, total body clearance (Cl/F) 0.20 l/hr* kg and 0.21 l/hr*kg and apparent volume of distribution (VD/F) 0.79 l/kg and 0.77 l/kg.

Keywords

Administration, rectal Pharmacokinetics Propanediols Propylene glycol Solution, rectal Solvents 

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Copyright information

© Kluwer Academic Publishers 1996

Authors and Affiliations

  • W. J. Kollöffel
    • 1
  • L. E. A. Weekers
    • 2
  • P. B. Goldhoorn
    • 2
  1. 1.Department of Clinical PharmacyTwenteborg Hospitalthe Netherlands
  2. 2.Department of Clinical PharmacyTwenteborg Hospitalthe Netherlands

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