Journal of Materials Science

, Volume 29, Issue 15, pp 4007–4012 | Cite as

Activation of human neutrophils by organic polymer surfaces

  • P. Falck


By means of lucigenin-dependent chemiluminescence it has been demonstrated that films of organic polymers activate human neutrophils. The strongest response was always induced by polyvinyl chloride-D and the smallest by polyethylene. No significant differences were found between the number of adherent cells on the surfaces of the investigated materials. The stimulatory capacity of the organic polymers were changed after adsorption of some plasma proteins. These effects were not connected with similar alterations of cell attachment. A second stimulation by opsonized zymosan was only possible for neutrophils adherent to polyether urethane and polyvinyl chloride-D.


Polymer Polyethylene Plasma Protein Material Processing Urethane 
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  1. 1.
    G. Busnach, B. Brando, A. Cappelleri, E. Sommaruga, C. Brunati and L. Minetti, Trans. Am. Soc. Artif. Intern. Organ XXXV (1989) 361.CrossRefGoogle Scholar
  2. 2.
    R. A. Ward, B. Sshmidt, M. Blumenstein and H. J. Gurland, Kid. Int. 37 (1990) 776.CrossRefGoogle Scholar
  3. 3.
    R. Schindler, G. Lonnemann, S. Shaldon, K. M. Koch and C. A. Dinarello, Contr. Nephrol. 74 (1988) 58.CrossRefGoogle Scholar
  4. 4.
    J. Janatova, A. K. Cheung and C. J. Parker, Complement. Inflamm. 8 (1991) 61.CrossRefGoogle Scholar
  5. 5.
    K. Cheung, A. C. Archibald and M. F. Robinson, J. Immunol. 130 (1983) 2324.Google Scholar
  6. 6.
    S. T. Hoffstein, R. M. Genarro and R. M. Manzi, Inflammation 9 (1985) 425.CrossRefGoogle Scholar
  7. 7.
    J.-C. Monboisse, R. Garnotel, A. Randoux, J. Dufer and J. P. Borel, J. Leukocyte Biol. 50 (1991) 373.CrossRefGoogle Scholar
  8. 8.
    G. A. Zimmerman, S. M. Prescott and T. M. Mcintire, Immunol. Today 13 (1992) 93.CrossRefGoogle Scholar
  9. 9.
    H. L. Malech and J. I. Gallin, New Engl. J. Med. 317 (1987) 687.CrossRefGoogle Scholar
  10. 10.
    A. T. Nguyen, C. Lethias, J. Zingraff, A. Hebrelin, C. Naret and B. Descamps-Latscha, Kid. Int. 28 (1985) 158.CrossRefGoogle Scholar
  11. 11.
    T. Kuwahara, M. Markert and J. P. Wauters, Nephrol Dial Transplant 3 (1988) 661.12CrossRefGoogle Scholar
  12. 12.
    A. Ferrante and Y. H. Thong, J. Immunol Methods 48 (1982) 81.CrossRefGoogle Scholar
  13. 13.
    G. F. Santini, S. Battistin, P. De Paoli, D. Vilalta, M. Borean and G. Basaglia, ibid. 100 (1987) 153.CrossRefGoogle Scholar
  14. 14.
    G. F. Weber, J. Clin. Chem. Clin. Biochem. 28 (1990) 569.Google Scholar
  15. 15.
    R. C. Allen, in “Bioluminescence and Chemiluminescence” edited by M. D. Luca and W. D. McElroy (Academic Press, New York, 1981) p. 63.CrossRefGoogle Scholar
  16. 16.
    R. W. Steele, Rev. Infect. Dis. 13 (1990) 918.CrossRefGoogle Scholar
  17. 17.
    A. Dekker, M. I. Hermanns, M. Valdor and C. J. Kirkpatrick, in “The Reference Materials of the European Communities” edited by W. Lemm (Kluwer Academic, Dordrecht, Boston, London, 1992) p. 201.CrossRefGoogle Scholar
  18. 18.
    T. Kuwahara, M. Marker and J. P. Wauters, Contr. Nephrol. 74 (1989) 52.CrossRefGoogle Scholar
  19. 19.
    R. O. Hynes, Cell 69 (1992) 11.CrossRefGoogle Scholar
  20. 20.
    B. Hall, D. J. Pearve, E. J. Campbell, A. M. Sullivan, R. R. C. New and S. A. Charles, in “The Reference Materials of the European Communities” edited by W. Lenn (Kluwer Academic, Dordrecht, Boston, London, 1992) p. 147.CrossRefGoogle Scholar
  21. 21.
    Y. K. Imai, K. Tajima and Y. Nose, Trans. Am. Soc. Artif. Intern. Organs 17 (1971) 6.Google Scholar
  22. 22.
    S. S. Kaplan, R. E. Basford, E. Mora, M. H. Jeong and R. L. Simmons, J. Biomed. Mater. Res. 26 (1992) 1039.CrossRefGoogle Scholar

Copyright information

© Chapman & Hall 1994

Authors and Affiliations

  • P. Falck
    • 1
  1. 1.School of Medicine, Biomaterial Research UnitHumboldt UniversityBerlinGermany

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