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Humangenetik

, Volume 25, Issue 4, pp 299–306 | Cite as

Bloom's syndrome and Fanconi's anemia: Demonstration of two distinctive patterns of chromosome disruption and rearrangement

  • Traute M. Schroeder
  • James German
Original Investigations

Summary

A comparison of the patterns of chromosome breakage and rearrangements was made using lymphocytes from one patient with Bloom's syndrome and one with Fanconi's anemia. Chromatid and isochromatid gaps and breaks were increased in frequency in both conditions. In Fanconi's anemia, more aberrations per aberrant cell occurred than in Bloom's syndrome. The relative numbers of the various classes of interchanges and the chromosome regions affected differed strikingly. In Bloom's syndrome, homologous chromosomes had formed most of the interchanges, while in Fanconi's anemia non-homologous chromosomes were preferentially involved in the interchanges. The patterns formed by brakage, including breaks involved in interchanges, show a non-random distribution of the lesions in both conditions.

Keywords

Internal Medicine Anemia Metabolic Disease Chromosome Region Distinctive Pattern 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag 1974

Authors and Affiliations

  • Traute M. Schroeder
    • 1
  • James German
    • 2
  1. 1.Institut für Anthropologie und HumangenetikHeidelberg
  2. 2.The New York Blood CenterNew York

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