Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

Prevalence of islet cell antibodies, insulin antibodies and hyperglycaemia in 2291 schoolchildren

  • 66 Accesses

  • 49 Citations


Islet cell antibodies, insulin antibodies and hyperglycaemia were investigated in 2291 healthy schoolchildren. Eight of the subjects had islet cell antibodies and eight had insulin antibodies. However, no schoolchild who was positive for islet cell antibodies also had insulin antibodies present. Hyperglycaemia was observed in five children but neither islet cell antibodies nor insulin antibodies could be detected in the sera from these particular subjects.


  1. 1.

    Betterle C, Zanette F, Pedini B, Presotto F, Rapp LB, Monciotti CM, Rigon F (1984) Clinical and subclinical autoimmune manifestations in Type 1 (insulin-dependent) diabetic patients and their first-degree relatives. Diabetologia 26: 431–436

  2. 2.

    Atkinson MA, Maclaren NK, Riley WJ, Winter WE, Fisk OD, Spillar RP (1986) Are insulin autoantibodies markers for insulin-dependent Diabetes Mellitus? Diabetes 35: 894–898

  3. 3.

    Srikanta S, Rickey AT, McCulloch DK, Soeldner JS, Eisenbarth GS, Palmer JP (1986) Autoimmunity to insulin, beta cell dysfunction and development of insulin-dependent diabetes mellitus. Diabetes 35: 139–142

  4. 4.

    Wilkin T, Armitage M, Casey C, Pyke DA, Hoskins PJ, Rodier M, Diaz JL, Leslie RDG (1985) Value of insulin autoantibodies as serum markers for insulin-dependent diabetes mellitus. Lancet 11: 480–484

  5. 5.

    McEvoy RC, Witt ME, Ginsberg-Fellner F, Rubinstein P (1986) Anti-insulin antibodies in children with Type 1 diabetes mellitus. Diabetes 35: 634–641

  6. 6.

    Spencer KM, Dean BM, Lister J, Bottazzo GF (1984) Fluctuating islet-cell autoimmunity in unaffected relatives of patients with insulin-dependent diabetes. Lancet I: 764–766

  7. 7.

    Kurtz AB, Matthews JA, Mustaffa BE, Dagget PR, Nabarro JDN (1980) Decrease of antibodies to insulin proinsulin and contaminating hormones after changing treatment from conventional beef to purified pork insulin. Diabetologia 18: 147–150

  8. 8.

    Bonifacio E, Dawkins RL, Lernmark A (1987) Immunology and Diabetes Workshop: Report of the Second International Workshop on the Standardisation of Cytoplasmic Islet Cell Antibodies. Diabetologia 30: 273

  9. 9.

    Barnett AH, Eff C, Leslie RDG, Pyke DA (1981) Diabetes in identical twins. Diabetologia 20: 87–93

  10. 10.

    Notsu K, Dka N, Note S, Nabeya N, Kuno S, Sakurami T (1985) Islet cell antibodies in the Japanese population and subjects with Type 1 (insulin-dependent) diabetes. Diabetologia 28: 660–662

Download references

Author information

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Bergua, M., Solé, J., Marion, G. et al. Prevalence of islet cell antibodies, insulin antibodies and hyperglycaemia in 2291 schoolchildren. Diabetologia 30, 724–726 (1987). https://doi.org/10.1007/BF00296996

Download citation

Key words

  • Islet cell antibodies
  • insulin antibodies
  • hyperglycaemia
  • schoolchildren
  • pre-Type 1 (insulin-dependent) diabetes